Welsch DJ - Search Results

1

Molecular cloning and expression of human leukotriene-C4 synthase.

Welsch DJ, Creely DP, Hauser SD, Mathis KJ, Krivi GG, Isakson PC. Welsch DJ, et al. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9745-9. doi: 10.1073/pnas.91.21.9745. Proc Natl Acad Sci U S A. 1994. PMID: 7937884 Free PMC article.

2

Molecular cloning and expression of human leukotriene C4 synthase.

Welsch DJ, Creely DP, Mathis KJ, Hauser SD, Isakson PC. Welsch DJ, et al. Adv Prostaglandin Thromboxane Leukot Res. 1995;23:167-9. Adv Prostaglandin Thromboxane Leukot Res. 1995. PMID: 7732826 No abstract available.

3

Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.

Becker DP, Barta TE, Bedell LJ, Boehm TL, Bond BR, Carroll J, Carron CP, Decrescenzo GA, Easton AM, Freskos JN, Funckes-Shippy CL, Heron M, Hockerman S, Howard CP, Kiefer JR, Li MH, Mathis KJ, McDonald JJ, Mehta PP, Munie GE, Sunyer T, Swearingen CA, Villamil CI, Welsch D, Williams JM, Yu Y, Yao J. Becker DP, et al. J Med Chem. 2010 Sep 23;53(18):6653-80. doi: 10.1021/jm100669j. J Med Chem. 2010. PMID: 20726512

4

The ligand-dependent interaction of mineralocorticoid receptor with coactivator and corepressor peptides suggests multiple activation mechanisms.

Hultman ML, Krasnoperova NV, Li S, Du S, Xia C, Dietz JD, Lala DS, Welsch DJ, Hu X. Hultman ML, et al. Among authors: welsch dj. Mol Endocrinol. 2005 Jun;19(6):1460-73. doi: 10.1210/me.2004-0537. Epub 2005 Mar 10. Mol Endocrinol. 2005. PMID: 15761029

5

Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols.

Freskos JN, Mischke BV, DeCrescenzo GA, Heintz R, Getman DP, Howard SC, Kishore NN, McDonald JJ, Munie GE, Rangwala S, Swearingen CA, Voliva C, Welsch DJ. Freskos JN, et al. Among authors: welsch dj. Bioorg Med Chem Lett. 1999 Apr 5;9(7):943-8. doi: 10.1016/s0960-894x(99)00116-x. Bioorg Med Chem Lett. 1999. PMID: 10230616

6

Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor.

Feng Y, Likos JJ, Zhu L, Woodward H, Munie G, McDonald JJ, Stevens AM, Howard CP, De Crescenzo GA, Welsch D, Shieh HS, Stallings WC. Feng Y, et al. Biochim Biophys Acta. 2002 Jul 29;1598(1-2):10-23. doi: 10.1016/s0167-4838(02)00307-2. Biochim Biophys Acta. 2002. PMID: 12147339

7

Discovery and development of a type II collagen neoepitope (TIINE) biomarker for matrix metalloproteinase activity: from in vitro to in vivo.

Nemirovskiy OV, Dufield DR, Sunyer T, Aggarwal P, Welsch DJ, Mathews WR. Nemirovskiy OV, et al. Among authors: welsch dj. Anal Biochem. 2007 Feb 1;361(1):93-101. doi: 10.1016/j.ab.2006.10.034. Epub 2006 Nov 15. Anal Biochem. 2007. PMID: 17187753

8

Association between concentrations of urinary type II collagen neoepitope (uTIINE) and joint space narrowing in patients with knee osteoarthritis.

Hellio Le Graverand MP, Brandt KD, Mazzuca SA, Katz BP, Buck R, Lane KA, Pickering E, Nemirovskiy OV, Sunyer T, Welsch DJ. Hellio Le Graverand MP, et al. Among authors: welsch dj. Osteoarthritis Cartilage. 2006 Nov;14(11):1189-95. doi: 10.1016/j.joca.2006.04.009. Epub 2006 Jun 6. Osteoarthritis Cartilage. 2006. PMID: 16753310 Free article. Clinical Trial.

9

1H, 13C and 15N resonance assignments for a truncated and inhibited catalytic domain of matrix metalloproteinase-2.

Feng Y, Likos J, Zhu L, Woodward H, McDonald J, Stevens A, Howard S, Welsch D. Feng Y, et al. J Biomol NMR. 2000 May;17(1):85-6. doi: 10.1023/a:1008393107234. J Biomol NMR. 2000. PMID: 10909870 No abstract available.

10

Irreversible degradation of histidine-96 of prothrombin fragment 1 during protein acetylation: another unusually reactive site in the kringle.

Welsch DJ, Nelsestuen GL. Welsch DJ, et al. Biochemistry. 1988 Sep 20;27(19):7513-9. doi: 10.1021/bi00419a050. Biochemistry. 1988. PMID: 3207687

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