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Heterogeneous endocrine cell composition defines human islet functional phenotypes.
Evans-Molina C, Pettway YD, Saunders DC, Sharp SA, Bate TS, Sun H, Durai H, Mei S, Coldren A, Davis C, Reihsmann CV, Hopkirk AL, Taylor J, Bradley A, Aramandla R, Poffenberger G, Eskaros A, Jenkins R, Shi D, Kang H, Rajesh V, Thaman S, Feng F, Cartailler JP, Powers AC, Abraham K, Gloyn AL, Niland JC, Brissova M. Evans-Molina C, et al. Among authors: bradley a. bioRxiv [Preprint]. 2024 Nov 21:2024.11.20.623809. doi: 10.1101/2024.11.20.623809. bioRxiv. 2024. PMID: 39605606 Free PMC article. Preprint.
Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial.
Werring DJ, Dehbi HM, Ahmed N, Arram L, Best JG, Balogun M, Bennett K, Bordea E, Caverly E, Chau M, Cohen H, Cullen M, Doré CJ, Engelter ST, Fenner R, Ford GA, Gill A, Hunter R, James M, Jayanthi A, Lip GYH, Massingham S, Murray ML, Mazurczak I, Nash PS, Ndoutoumou A, Norrving B, Sims H, Sprigg N, Vanniyasingam T, Freemantle N; OPTIMAS investigators. Werring DJ, et al. Lancet. 2024 Oct 23:S0140-6736(24)02197-4. doi: 10.1016/S0140-6736(24)02197-4. Online ahead of print. Lancet. 2024. PMID: 39491870 Free article.
Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners.
Coate KC, Dai C, Singh A, Stanley J, Covington BA, Bradley A, Oladipupo F, Gong Y, Wisniewski S, Sellick K, Spears E, Poffenberger G, Schornack AMR, Bustabad A, Rodgers T, Dey N, Shultz LD, Greiner DL, Yan H, Powers AC, Chen W, Dean ED. Coate KC, et al. Among authors: bradley a. Mol Metab. 2024 Dec;90:102050. doi: 10.1016/j.molmet.2024.102050. Epub 2024 Oct 20. Mol Metab. 2024. PMID: 39433176 Free PMC article.
Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines.
Elrick H, Peterson KA, Willis BJ, Lanza DG, Acar EF, Ryder EJ, Teboul L, Kasparek P, Birling MC, Adams DJ, Bradley A, Braun RE, Brown SD, Caulder A, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Duddy G, Gertsenstein M, Goodwin LO, Hérault Y, Lintott LG, Lloyd KCK, Lorenzo I, Mackenzie M, Mallon AM, McKerlie C, Parkinson H, Ramirez-Solis R, Seavitt JR, Sedlacek R, Skarnes WC, Smedley D, Wells S, White JK, Wood JA; International Mouse Phenotyping Consortium; Murray SA, Heaney JD, Nutter LMJ. Elrick H, et al. Among authors: bradley a. Sci Rep. 2024 Sep 30;14(1):22626. doi: 10.1038/s41598-024-72418-8. Sci Rep. 2024. PMID: 39349521 Free PMC article.
1,410 results