Perkins W - Search Results

1

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

Seibert K, Zhang Y, Leahy K, Hauser S, Masferrer J, Perkins W, Lee L, Isakson P. Seibert K, et al. Among authors: perkins w. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12013-7. doi: 10.1073/pnas.91.25.12013. Proc Natl Acad Sci U S A. 1994. PMID: 7991575 Free PMC article.

2

Mediation of inflammation by cyclooxygenase-2.

Seibert K, Masferrer J, Zhang Y, Gregory S, Olson G, Hauser S, Leahy K, Perkins W, Isakson P. Seibert K, et al. Among authors: perkins w. Agents Actions Suppl. 1995;46:41-50. doi: 10.1007/978-3-0348-7276-8_5. Agents Actions Suppl. 1995. PMID: 7610990 Review.

3

Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.

Li JJ, Norton MB, Reinhard EJ, Anderson GD, Gregory SA, Isakson PC, Koboldt CM, Masferrer JL, Perkins WE, Seibert K, Zhang Y, Zweifel BS, Reitz DB. Li JJ, et al. Among authors: perkins we. J Med Chem. 1996 Apr 26;39(9):1846-56. doi: 10.1021/jm950878e. J Med Chem. 1996. PMID: 8627608

4

Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents.

Khanna IK, Yu Y, Huff RM, Weier RM, Xu X, Koszyk FJ, Collins PW, Cogburn JN, Isakson PC, Koboldt CM, Masferrer JL, Perkins WE, Seibert K, Veenhuizen AW, Yuan J, Yang DC, Zhang YY. Khanna IK, et al. Among authors: perkins we. J Med Chem. 2000 Aug 10;43(16):3168-85. doi: 10.1021/jm0000719. J Med Chem. 2000. PMID: 10956225

5

Diarylspiro[2.4]heptenes as orally active, highly selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationships.

Huang HC, Li JJ, Garland DJ, Chamberlain TS, Reinhard EJ, Manning RE, Seibert K, Koboldt CM, Gregory SA, Anderson GD, Veenhuizen AW, Zhang Y, Perkins WE, Burton EG, Cogburn JN, Isakson PC, Reitz DB. Huang HC, et al. Among authors: perkins we. J Med Chem. 1996 Jan 5;39(1):253-66. doi: 10.1021/jm950664x. J Med Chem. 1996. PMID: 8568815

6

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

Penning TD, Talley JJ, Bertenshaw SR, Carter JS, Collins PW, Docter S, Graneto MJ, Lee LF, Malecha JW, Miyashiro JM, Rogers RS, Rogier DJ, Yu SS, AndersonGD, Burton EG, Cogburn JN, Gregory SA, Koboldt CM, Perkins WE, Seibert K, Veenhuizen AW, Zhang YY, Isakson PC. Penning TD, et al. Among authors: perkins we. J Med Chem. 1997 Apr 25;40(9):1347-65. doi: 10.1021/jm960803q. J Med Chem. 1997. PMID: 9135032

7

1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents.

Khanna IK, Weier RM, Yu Y, Xu XD, Koszyk FJ, Collins PW, Koboldt CM, Veenhuizen AW, Perkins WE, Casler JJ, Masferrer JL, Zhang YY, Gregory SA, Seibert K, Isakson PC. Khanna IK, et al. Among authors: perkins we. J Med Chem. 1997 May 23;40(11):1634-47. doi: 10.1021/jm9700225. J Med Chem. 1997. PMID: 9171873

8

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2.

Talley JJ, Brown DL, Carter JS, Graneto MJ, Koboldt CM, Masferrer JL, Perkins WE, Rogers RS, Shaffer AF, Zhang YY, Zweifel BS, Seibert K. Talley JJ, et al. Among authors: perkins we. J Med Chem. 2000 Mar 9;43(5):775-7. doi: 10.1021/jm990577v. J Med Chem. 2000. PMID: 10715145 No abstract available.

9

Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors.

Reitz DB, Li JJ, Norton MB, Reinhard EJ, Collins JT, Anderson GD, Gregory SA, Koboldt CM, Perkins WE, Seibert K, et al. Reitz DB, et al. Among authors: perkins we. J Med Chem. 1994 Nov 11;37(23):3878-81. doi: 10.1021/jm00049a005. J Med Chem. 1994. PMID: 7966148 No abstract available.

10

Polymer delivery of the active isomer of misoprostol: a solution to the intestinal side effect problem.

Perkins WE, Bianchi RG, Tremont SJ, Collins PW, Casler JJ, Fenton RL, Wagner GM, McGrath MP, Stolzenbach JC, Kowalski DL, et al. Perkins WE, et al. J Pharmacol Exp Ther. 1994 Apr;269(1):151-6. J Pharmacol Exp Ther. 1994. PMID: 8169819

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