Gibbs JB - Search Results

1

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic.

Gibbs JB, Oliff A, Kohl NE. Gibbs JB, et al. Cell. 1994 Apr 22;77(2):175-8. doi: 10.1016/0092-8674(94)90308-5. Cell. 1994. PMID: 8168127 Review. No abstract available.

2

Pharmaceutical research in molecular oncology.

Gibbs JB, Oliff A. Gibbs JB, et al. Cell. 1994 Oct 21;79(2):193-8. doi: 10.1016/0092-8674(94)90189-9. Cell. 1994. PMID: 7954788 Review. No abstract available.

3

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton.

Prendergast GC, Davide JP, deSolms SJ, Giuliani EA, Graham SL, Gibbs JB, Oliff A, Kohl NE. Prendergast GC, et al. Among authors: gibbs jb. Mol Cell Biol. 1994 Jun;14(6):4193-202. doi: 10.1128/mcb.14.6.4193-4202.1994. Mol Cell Biol. 1994. PMID: 8196657 Free PMC article.

4

Negative growth selection against rodent fibroblasts targeted for genetic inhibition of farnesyl transferase.

Prendergast GC, Davide JP, Kral A, Diehl R, Gibbs JB, Omer CA, Kohl NE. Prendergast GC, et al. Among authors: gibbs jb. Cell Growth Differ. 1993 Sep;4(9):707-13. Cell Growth Differ. 1993. PMID: 8241019

5

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor.

Kohl NE, Mosser SD, deSolms SJ, Giuliani EA, Pompliano DL, Graham SL, Smith RL, Scolnick EM, Oliff A, Gibbs JB. Kohl NE, et al. Among authors: gibbs jb. Science. 1993 Jun 25;260(5116):1934-7. doi: 10.1126/science.8316833. Science. 1993. PMID: 8316833

6

Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.

Gibbs JB, Pompliano DL, Mosser SD, Rands E, Lingham RB, Singh SB, Scolnick EM, Kohl NE, Oliff A. Gibbs JB, et al. J Biol Chem. 1993 Apr 15;268(11):7617-20. J Biol Chem. 1993. PMID: 8463291 Free article.

7

Inhibition of Ras function in vitro and in vivo using inhibitors of farnesyl-protein transferase.

Kohl NE, Wilson FR, Thomas TJ, Bock RL, Mosser SD, Oliff A, Gibbs JB. Kohl NE, et al. Among authors: gibbs jb. Methods Enzymol. 1995;255:378-86. doi: 10.1016/s0076-6879(95)55040-2. Methods Enzymol. 1995. PMID: 8524123 No abstract available.

8

Development of inhibitors of protein farnesylation as potential chemotherapeutic agents.

Kohl NE, Conner MW, Gibbs JB, Graham SL, Hartman GD, Oliff A. Kohl NE, et al. Among authors: gibbs jb. J Cell Biochem Suppl. 1995;22:145-50. doi: 10.1002/jcb.240590819. J Cell Biochem Suppl. 1995. PMID: 8538192 Review.

9

2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.

Williams TM, Ciccarone TM, MacTough SC, Bock RL, Conner MW, Davide JP, Hamilton K, Koblan KS, Kohl NE, Kral AM, Mosser SD, Omer CA, Pompliano DL, Rands E, Schaber MD, Shah D, Wilson FR, Gibbs JB, Graham SL, Hartman GD, Oliff AI, Smith RL. Williams TM, et al. Among authors: gibbs jb. J Med Chem. 1996 Mar 29;39(7):1345-8. doi: 10.1021/jm9508090. J Med Chem. 1996. PMID: 8691462 No abstract available.

10

Farnesyltransferase inhibitors and anti-Ras therapy.

Gibbs JB, Kohl NE, Koblan KS, Omer CA, Sepp-Lorenzino L, Rosen N, Anthony NJ, Conner MW, deSolms SJ, Williams TM, Graham SL, Hartman GD, Oliff A. Gibbs JB, et al. Breast Cancer Res Treat. 1996;38(1):75-83. doi: 10.1007/BF01803786. Breast Cancer Res Treat. 1996. PMID: 8825125 Review.

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