Ward SA - Search Results

1

The effect of fluorine substitution on the metabolism and antimalarial activity of amodiaquine.

O'Neill PM, Harrison AC, Storr RC, Hawley SR, Ward SA, Park BK. O'Neill PM, et al. Among authors: ward sa. J Med Chem. 1994 Apr 29;37(9):1362-70. doi: 10.1021/jm00035a017. J Med Chem. 1994. PMID: 8176713

2

Vacuolar acidification and chloroquine sensitivity in Plasmodium falciparum.

Bray PG, Howells RE, Ward SA. Bray PG, et al. Among authors: ward sa. Biochem Pharmacol. 1992 Mar 17;43(6):1219-27. doi: 10.1016/0006-2952(92)90495-5. Biochem Pharmacol. 1992. PMID: 1562274

3

Effect of chloroquine and primaquine on antipyrine metabolism.

Back DJ, Purba HS, Park BK, Ward SA, Orme ML. Back DJ, et al. Among authors: ward sa. Br J Clin Pharmacol. 1983 Nov;16(5):497-502. doi: 10.1111/j.1365-2125.1983.tb02206.x. Br J Clin Pharmacol. 1983. PMID: 6639836 Free PMC article.

4

Current views on the mechanisms of resistance to quinoline-containing drugs in Plasmodium falciparum.

Ward SA, Bray PG, Mungthin M, Hawley SR. Ward SA, et al. Ann Trop Med Parasitol. 1995 Apr;89(2):121-4. doi: 10.1080/00034983.1995.11812942. Ann Trop Med Parasitol. 1995. PMID: 7605121

5

The effect of chemical substitution on the metabolic activation, metabolic detoxication, and pharmacological activity of amodiaquine in the mouse.

Ruscoe JE, Jewell H, Maggs JL, O'Neill PM, Storr RC, Ward SA, Park BK. Ruscoe JE, et al. Among authors: ward sa. J Pharmacol Exp Ther. 1995 Apr;273(1):393-404. J Pharmacol Exp Ther. 1995. PMID: 7714794

6

Relationship of global chloroquine transport and reversal of resistance in Plasmodium falciparum.

Bray PG, Boulter MK, Ritchie GY, Howells RE, Ward SA. Bray PG, et al. Among authors: ward sa. Mol Biochem Parasitol. 1994 Jan;63(1):87-94. doi: 10.1016/0166-6851(94)90011-6. Mol Biochem Parasitol. 1994. PMID: 8183326

7

The role of drug accumulation in 4-aminoquinoline antimalarial potency. The influence of structural substitution and physicochemical properties.

Hawley SR, Bray PG, O'Neill PM, Park BK, Ward SA. Hawley SR, et al. Among authors: ward sa. Biochem Pharmacol. 1996 Sep 13;52(5):723-33. doi: 10.1016/0006-2952(96)00354-1. Biochem Pharmacol. 1996. PMID: 8765470

8

Amodiaquine accumulation in Plasmodium falciparum as a possible explanation for its superior antimalarial activity over chloroquine.

Hawley SR, Bray PG, Park BK, Ward SA. Hawley SR, et al. Among authors: ward sa. Mol Biochem Parasitol. 1996 Sep;80(1):15-25. doi: 10.1016/0166-6851(96)02655-2. Mol Biochem Parasitol. 1996. PMID: 8885219

9

Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component.

Hawley SR, Bray PG, O'Neill PM, Naisbitt DJ, Park BK, Ward SA. Hawley SR, et al. Among authors: ward sa. Antimicrob Agents Chemother. 1996 Oct;40(10):2345-9. doi: 10.1128/AAC.40.10.2345. Antimicrob Agents Chemother. 1996. PMID: 8891142 Free PMC article.

10

Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of benzylamino and alkylamino ether analogues of artemisinin.

O'Neill PM, Bishop LP, Storr RC, Hawley SR, Maggs JL, Ward SA, Park BK. O'Neill PM, et al. Among authors: ward sa. J Med Chem. 1996 Oct 25;39(22):4511-4. doi: 10.1021/jm9604944. J Med Chem. 1996. PMID: 8893847

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