Thompson WJ - Search Results

1

Sulfonylmethanesulfonamide inhibitors of carbonic anhydrase.

Scholz TH, Sondey JM, Randall WC, Schwam H, Thompson WJ, Mallorga PJ, Sugrue MF, Graham SL. Scholz TH, et al. Among authors: thompson wj. J Med Chem. 1993 Jul 23;36(15):2134-41. doi: 10.1021/jm00067a012. J Med Chem. 1993. PMID: 8340917

2

HIV-1 protease inhibitors based on hydroxyethylene dipeptide isosteres: an investigation into the role of the P1' side chain on structure-activity.

Young SD, Payne LS, Thompson WJ, Gaffin N, Lyle TA, Britcher SF, Graham SL, Schultz TH, Deana AA, Darke PL, et al. Young SD, et al. Among authors: thompson wj. J Med Chem. 1992 May 15;35(10):1702-9. doi: 10.1021/jm00088a004. J Med Chem. 1992. PMID: 1588552

3

The development of cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors.

Ghosh AK, Lee HY, Thompson WJ, Culberson C, Holloway MK, McKee SP, Munson PM, Duong TT, Smith AM, Darke PL, et al. Ghosh AK, et al. Among authors: thompson wj. J Med Chem. 1994 Apr 15;37(8):1177-88. doi: 10.1021/jm00034a016. J Med Chem. 1994. PMID: 8164260

4

Structure and activity of hydrogenated derivatives of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801).

Lyle TA, Magill CA, Britcher SF, Denny GH, Thompson WJ, Murphy JS, Knight AR, Kemp JA, Marshall GR, Middlemiss DN, et al. Lyle TA, et al. Among authors: thompson wj. J Med Chem. 1990 Mar;33(3):1047-52. doi: 10.1021/jm00165a026. J Med Chem. 1990. PMID: 2155319

5

Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands.

Ghosh AK, Thompson WJ, Holloway MK, McKee SP, Duong TT, Lee HY, Munson PM, Smith AM, Wai JM, Darke PL, et al. Ghosh AK, et al. Among authors: thompson wj. J Med Chem. 1993 Aug 6;36(16):2300-10. doi: 10.1021/jm00068a006. J Med Chem. 1993. PMID: 8360874

6

3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors.

Ghosh AK, Thompson WJ, McKee SP, Duong TT, Lyle TA, Chen JC, Darke PL, Zugay JA, Emini EA, Schleif WA, et al. Ghosh AK, et al. Among authors: thompson wj. J Med Chem. 1993 Jan 22;36(2):292-4. doi: 10.1021/jm00054a015. J Med Chem. 1993. PMID: 8423600 No abstract available.

7

Cyclic sulfolanes as novel and high affinity P2 ligands for HIV-1 protease inhibitors.

Ghosh AK, Thompson WJ, Lee HY, McKee SP, Munson PM, Duong TT, Darke PL, Zugay JA, Emini EA, Schleif WA, et al. Ghosh AK, et al. Among authors: thompson wj. J Med Chem. 1993 Apr 2;36(7):924-7. doi: 10.1021/jm00059a019. J Med Chem. 1993. PMID: 8464047 No abstract available.

8

Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl substituents: X-ray crystal structure assisted design.

Thompson WJ, Fitzgerald PM, Holloway MK, Emini EA, Darke PL, McKeever BM, Schleif WA, Quintero JC, Zugay JA, Tucker TJ, et al. Thompson WJ, et al. J Med Chem. 1992 May 15;35(10):1685-701. doi: 10.1021/jm00088a003. J Med Chem. 1992. PMID: 1588551

9

Benzocycloalkyl amines as novel C-termini for HIV protease inhibitors.

Lyle TA, Wiscount CM, Guare JP, Thompson WJ, Anderson PS, Darke PL, Zugay ZA, Emini EA, Schleif WA, Qunitero JC, et al. Lyle TA, et al. Among authors: thompson wj. J Med Chem. 1991 Mar;34(3):1228-30. doi: 10.1021/jm00107a051. J Med Chem. 1991. PMID: 2002466 No abstract available.

10

A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site.

Holloway MK, Wai JM, Halgren TA, Fitzgerald PM, Vacca JP, Dorsey BD, Levin RB, Thompson WJ, Chen LJ, deSolms SJ. Holloway MK, et al. Among authors: thompson wj. J Med Chem. 1995 Jan 20;38(2):305-17. doi: 10.1021/jm00002a012. J Med Chem. 1995. PMID: 7830273

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