Wu WY - Search Results

1

Rational design of potent sialidase-based inhibitors of influenza virus replication.

von Itzstein M, Wu WY, Kok GB, Pegg MS, Dyason JC, Jin B, Van Phan T, Smythe ML, White HF, Oliver SW, et al. von Itzstein M, et al. Among authors: wu wy. Nature. 1993 Jun 3;363(6428):418-23. doi: 10.1038/363418a0. Nature. 1993. PMID: 8502295

2

The synthesis of 2,3-didehydro-2,4-dideoxy-4-guanidinyl-N-acetylneuraminic acid: a potent influenza virus sialidase inhibitor.

von Itzstein M, Wu WY, Jin B. von Itzstein M, et al. Among authors: wu wy. Carbohydr Res. 1994 Jun 17;259(2):301-5. doi: 10.1016/0008-6215(94)84065-2. Carbohydr Res. 1994. PMID: 8050102 No abstract available.

3

Inhibition of sialidases from viral, bacterial and mammalian sources by analogues of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid modified at the C-4 position.

Holzer CT, von Itzstein M, Jin B, Pegg MS, Stewart WP, Wu WY. Holzer CT, et al. Among authors: wu wy. Glycoconj J. 1993 Feb;10(1):40-4. doi: 10.1007/BF00731185. Glycoconj J. 1993. PMID: 8358225

4

A study of the active site of influenza virus sialidase: an approach to the rational design of novel anti-influenza drugs.

von Itzstein M, Dyason JC, Oliver SW, White HF, Wu WY, Kok GB, Pegg MS. von Itzstein M, et al. Among authors: wu wy. J Med Chem. 1996 Jan 19;39(2):388-91. doi: 10.1021/jm950294c. J Med Chem. 1996. PMID: 8558506

5

Highly potent and long-acting trimeric and tetrameric inhibitors of influenza virus neuraminidase.

Watson KG, Cameron R, Fenton RJ, Gower D, Hamilton S, Jin B, Krippner GY, Luttick A, McConnell D, MacDonald SJ, Mason AM, Nguyen V, Tucker SP, Wu WY. Watson KG, et al. Among authors: wu wy. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1589-92. doi: 10.1016/j.bmcl.2003.09.102. Bioorg Med Chem Lett. 2004. PMID: 15006410

6

Synthesis of a polymeric 4-N-linked sialoside which inhibits influenza virus hemagglutinin.

Wu WY, Jin B, Krippner GY, Watson KG. Wu WY, et al. Bioorg Med Chem Lett. 2000 Feb 21;10(4):341-3. doi: 10.1016/s0960-894x(00)00007-x. Bioorg Med Chem Lett. 2000. PMID: 10714495

7

Tethered neuraminidase inhibitors that bind an influenza virus: a first step towards a diagnostic method for influenza.

McKimm-Breschkin JL, Colman PM, Jin B, Krippner GY, McDonald M, Reece PA, Tucker SP, Waddington L, Watson KG, Wu WY. McKimm-Breschkin JL, et al. Among authors: wu wy. Angew Chem Int Ed Engl. 2003 Jul 14;42(27):3118-21. doi: 10.1002/anie.200250402. Angew Chem Int Ed Engl. 2003. PMID: 12866095 No abstract available.

8

Potent and long-acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimen.

Macdonald SJ, Watson KG, Cameron R, Chalmers DK, Demaine DA, Fenton RJ, Gower D, Hamblin JN, Hamilton S, Hart GJ, Inglis GG, Jin B, Jones HT, McConnell DB, Mason AM, Nguyen V, Owens IJ, Parry N, Reece PA, Shanahan SE, Smith D, Wu WY, Tucker SP. Macdonald SJ, et al. Among authors: wu wy. Antimicrob Agents Chemother. 2004 Dec;48(12):4542-9. doi: 10.1128/AAC.48.12.4542-4549.2004. Antimicrob Agents Chemother. 2004. PMID: 15561823 Free PMC article.

9

Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza.

Macdonald SJ, Cameron R, Demaine DA, Fenton RJ, Foster G, Gower D, Hamblin JN, Hamilton S, Hart GJ, Hill AP, Inglis GG, Jin B, Jones HT, McConnell DB, McKimm-Breschkin J, Mills G, Nguyen V, Owens IJ, Parry N, Shanahan SE, Smith D, Watson KG, Wu WY, Tucker SP. Macdonald SJ, et al. Among authors: wu wy. J Med Chem. 2005 Apr 21;48(8):2964-71. doi: 10.1021/jm040891b. J Med Chem. 2005. PMID: 15828835

10

An orally bioavailable oxime ether capsid binder with potent activity against human rhinovirus.

Watson KG, Brown RN, Cameron R, Chalmers DK, Hamilton S, Jin B, Krippner GY, Luttick A, McConnell DB, Reece PA, Ryan J, Stanislawski PC, Tucker SP, Wu WY, Barnard DL, Sidwell RW. Watson KG, et al. Among authors: wu wy. J Med Chem. 2003 Jul 17;46(15):3181-4. doi: 10.1021/jm0202876. J Med Chem. 2003. PMID: 12852746

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