Savino R - Search Results

1

Definition of a composite binding site for gp130 in human interleukin-6.

Ciapponi L, Graziani R, Paonessa G, Lahm A, Ciliberto G, Savino R. Ciapponi L, et al. Among authors: savino r. J Biol Chem. 1995 Dec 29;270(52):31249-54. doi: 10.1074/jbc.270.52.31249. J Biol Chem. 1995. PMID: 8537391 Free article.

2

Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.

Savino R, Lahm A, Salvati AL, Ciapponi L, Sporeno E, Altamura S, Paonessa G, Toniatti C, Ciliberto G. Savino R, et al. EMBO J. 1994 Mar 15;13(6):1357-67. doi: 10.1002/j.1460-2075.1994.tb06389.x. EMBO J. 1994. PMID: 7511100 Free PMC article.

3

The molecular design of human IL-6 receptor antagonists.

Lahm A, Savino R, Salvati AL, Cabibbo A, Ciapponi L, Demartis A, Toniatti C, Paonessa G, Altamura S, Ciliberto G. Lahm A, et al. Among authors: savino r. Ann N Y Acad Sci. 1995 Jul 21;762:136-50; discussion 150-1. doi: 10.1111/j.1749-6632.1995.tb32322.x. Ann N Y Acad Sci. 1995. PMID: 7668525 No abstract available.

4

Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.

Paonessa G, Graziani R, De Serio A, Savino R, Ciapponi L, Lahm A, Salvati AL, Toniatti C, Ciliberto G. Paonessa G, et al. Among authors: savino r. EMBO J. 1995 May 1;14(9):1942-51. doi: 10.1002/j.1460-2075.1995.tb07186.x. EMBO J. 1995. PMID: 7744001 Free PMC article.

5

Rational design of a receptor super-antagonist of human interleukin-6.

Savino R, Ciapponi L, Lahm A, Demartis A, Cabibbo A, Toniatti C, Delmastro P, Altamura S, Ciliberto G. Savino R, et al. EMBO J. 1994 Dec 15;13(24):5863-70. doi: 10.1002/j.1460-2075.1994.tb06931.x. EMBO J. 1994. PMID: 7813426 Free PMC article.

6

Saturation mutagenesis of the human interleukin 6 receptor-binding site: implications for its three-dimensional structure.

Savino R, Lahm A, Giorgio M, Cabibbo A, Tramontano A, Ciliberto G. Savino R, et al. Proc Natl Acad Sci U S A. 1993 May 1;90(9):4067-71. doi: 10.1073/pnas.90.9.4067. Proc Natl Acad Sci U S A. 1993. PMID: 8483922 Free PMC article.

7

Monovalent phage display of human interleukin (hIL)-6: selection of superbinder variants from a complex molecular repertoire in the hIL-6 D-helix.

Cabibbo A, Sporeno E, Toniatti C, Altamura S, Savino R, Paonessa G, Ciliberto G. Cabibbo A, et al. Among authors: savino r. Gene. 1995 Dec 29;167(1-2):41-7. doi: 10.1016/0378-1119(95)00632-x. Gene. 1995. PMID: 8566809

8

Human interleukin-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells.

Sporeno E, Savino R, Ciapponi L, Paonessa G, Cabibbo A, Lahm A, Pulkki K, Sun RX, Toniatti C, Klein B, Ciliberto G. Sporeno E, et al. Among authors: savino r. Blood. 1996 Jun 1;87(11):4510-9. Blood. 1996. PMID: 8639818 Free article.

9

Interleukin 6 receptor superantagonists are potent inducers of human multiple myeloma cell death.

Demartis A, Bernassola F, Savino R, Melino G, Ciliberto G. Demartis A, et al. Among authors: savino r. Cancer Res. 1996 Sep 15;56(18):4213-8. Cancer Res. 1996. PMID: 8797594

10

Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist.

Ciapponi L, Maione D, Scoumanne A, Costa P, Hansen MB, Svenson M, Bendtzen K, Alonzi T, Paonessa G, Cortese R, Ciliberto G, Savino R. Ciapponi L, et al. Among authors: savino r. Nat Biotechnol. 1997 Oct;15(10):997-1001. doi: 10.1038/nbt1097-997. Nat Biotechnol. 1997. PMID: 9335053

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