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Orally active squalene synthase inhibitors: bis((acyloxy)alkyl) prodrugs of the alpha-phosphonosulfonic acid moiety.
Dickson JK Jr, Biller SA, Magnin DR, Petrillo EW Jr, Hillyer JW, Hsieh DC, Lan SJ, Rinehart JK, Gregg RE, Harrity TW, Jolibois KG, Kalinowski SS, Kunselman LK, Mookhtiar KA, Ciosek CP Jr. Dickson JK Jr, et al. Among authors: mookhtiar ka. J Med Chem. 1996 Feb 2;39(3):661-4. doi: 10.1021/jm950735s. J Med Chem. 1996. PMID: 8576906 No abstract available.
Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves beta-cell function in db/db mice.
Harrity T, Farrelly D, Tieman A, Chu C, Kunselman L, Gu L, Ponticiello R, Cap M, Qu F, Shao C, Wang W, Zhang H, Fenderson W, Chen S, Devasthale P, Jeon Y, Seethala R, Yang WP, Ren J, Zhou M, Ryono D, Biller S, Mookhtiar KA, Wetterau J, Gregg R, Cheng PT, Hariharan N. Harrity T, et al. Among authors: mookhtiar ka. Diabetes. 2006 Jan;55(1):240-8. Diabetes. 2006. PMID: 16380499
Glucolipsin A and B, two new glucokinase activators produced by Streptomyces purpurogeniscleroticus and Nocardia vaccinii.
Qian-Cutrone J, Ueki T, Huang S, Mookhtiar KA, Ezekiel R, Kalinowski SS, Brown KS, Golik J, Lowe S, Pirnik DM, Hugill R, Veitch JA, Klohr SE, Whitney JL, Manly SP. Qian-Cutrone J, et al. Among authors: mookhtiar ka. J Antibiot (Tokyo). 1999 Mar;52(3):245-55. doi: 10.7164/antibiotics.52.245. J Antibiot (Tokyo). 1999. PMID: 10348039 Free article.
Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A2A Receptor Antagonists and Their Biological Evaluation.
Basu S, Barawkar DA, Thorat S, Shejul YD, Patel M, Naykodi M, Jain V, Salve Y, Prasad V, Chaudhary S, Ghosh I, Bhat G, Quraishi A, Patil H, Ansari S, Menon S, Unadkat V, Thakare R, Seervi MS, Meru AV, De S, Bhamidipati RK, Rouduri SR, Palle VP, Chug A, Mookhtiar KA. Basu S, et al. Among authors: mookhtiar ka. J Med Chem. 2017 Jan 26;60(2):681-694. doi: 10.1021/acs.jmedchem.6b01584. Epub 2017 Jan 17. J Med Chem. 2017. PMID: 28055204
49 results