Seppen J - Search Results

1

A mutation which disrupts the hydrophobic core of the signal peptide of bilirubin UDP-glucuronosyltransferase, an endoplasmic reticulum membrane protein, causes Crigler-Najjar type II.

Seppen J, Steenken E, Lindhout D, Bosma PJ, Elferink RP. Seppen J, et al. FEBS Lett. 1996 Jul 29;390(3):294-8. doi: 10.1016/0014-5793(96)00677-1. FEBS Lett. 1996. PMID: 8706880 Free article.

2

Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase.

Seppen J, Bosma PJ, Goldhoorn BG, Bakker CT, Chowdhury JR, Chowdhury NR, Jansen PL, Oude Elferink RP. Seppen J, et al. J Clin Invest. 1994 Dec;94(6):2385-91. doi: 10.1172/JCI117604. J Clin Invest. 1994. PMID: 7989595 Free PMC article.

3

Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man.

Bosma PJ, Seppen J, Goldhoorn B, Bakker C, Oude Elferink RP, Chowdhury JR, Chowdhury NR, Jansen PL. Bosma PJ, et al. Among authors: seppen j. J Biol Chem. 1994 Jul 8;269(27):17960-4. J Biol Chem. 1994. PMID: 8027054 Free article.

4

Bilirubin glucuronidation by intact Gunn rat fibroblasts expressing bilirubin UDP-glucuronosyltransferase.

Seppen J, Tada K, Hellwig S, Bakker CT, Prasad VR, Roy Chowdhury N, Roy Chowdhury J, Bosma PJ, Oude Elferink RP. Seppen J, et al. Biochem J. 1996 Mar 1;314 ( Pt 2)(Pt 2):477-83. doi: 10.1042/bj3140477. Biochem J. 1996. PMID: 8670060 Free PMC article.

5

Transplantation of Gunn rats with autologous fibroblasts expressing bilirubin UDP-glucuronosyltransferase: correction of genetic deficiency and tumor formation.

Seppen J, Tada K, Ottenhoff R, Sengupta K, Chowdhury NR, Chowdhury JR, Bosma PJ, Oude Elferink RP. Seppen J, et al. Hum Gene Ther. 1997 Jan 1;8(1):27-36. doi: 10.1089/hum.1997.8.1-27. Hum Gene Ther. 1997. PMID: 8989992

6

Immune response to lentiviral bilirubin UDP-glucuronosyltransferase gene transfer in fetal and neonatal rats.

Seppen J, van Til NP, van der Rijt R, Hiralall JK, Kunne C, Elferink RP. Seppen J, et al. Gene Ther. 2006 Apr;13(8):672-7. doi: 10.1038/sj.gt.3302681. Gene Ther. 2006. PMID: 16267566

7

Adeno-associated virus vector serotypes mediate sustained correction of bilirubin UDP glucuronosyltransferase deficiency in rats.

Seppen J, Bakker C, de Jong B, Kunne C, van den Oever K, Vandenberghe K, de Waart R, Twisk J, Bosma P. Seppen J, et al. Mol Ther. 2006 Jun;13(6):1085-92. doi: 10.1016/j.ymthe.2006.01.014. Epub 2006 Apr 3. Mol Ther. 2006. PMID: 16581301 Free article.

8

Reduction of liver macrophage transduction by pseudotyping lentiviral vectors with a fusion envelope from Autographa californica GP64 and Sendai virus F2 domain.

Markusic DM, van Til NP, Hiralall JK, Elferink RP, Seppen J. Markusic DM, et al. Among authors: seppen j. BMC Biotechnol. 2009 Oct 7;9:85. doi: 10.1186/1472-6750-9-85. BMC Biotechnol. 2009. PMID: 19811629 Free PMC article.

9

Biliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo.

van Dijk R, Aronson SJ, de Waart DR, van de Graaf SF, Duijst S, Seppen J, Elferink RO, Beuers U, Bosma PJ. van Dijk R, et al. Among authors: seppen j. Sci Rep. 2017 May 10;7(1):1646. doi: 10.1038/s41598-017-01602-w. Sci Rep. 2017. PMID: 28490767 Free PMC article.

10

In vitro functionality of human fetal liver cells and clonal derivatives under proliferative conditions.

Deurholt T, ten Bloemendaal L, Chhatta AA, van Wijk AC, Weijer K, Seppen J, Elferink RP, Chamuleau RA, Hoekstra R. Deurholt T, et al. Among authors: seppen j. Cell Transplant. 2006;15(8-9):811-22. doi: 10.3727/000000006783464417. Cell Transplant. 2006. PMID: 17269451 Free article.

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