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6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells.
Nielsen FE, Bodvarsdottir TB, Worsaae A, MacKay P, Stidsen CE, Boonen HC, Pridal L, Arkhammar PO, Wahl P, Ynddal L, Junager F, Dragsted N, Tagmose TM, Mogensen JP, Koch A, Treppendahl SP, Hansen JB. Nielsen FE, et al. Among authors: worsaae a. J Med Chem. 2002 Sep 12;45(19):4171-87. doi: 10.1021/jm0208121. J Med Chem. 2002. PMID: 12213059
Synthesis and pharmacological evaluation of 4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels.
Schou SC, Hansen HC, Tagmose TM, Boonen HC, Worsaae A, Drabowski M, Wahl P, Arkhammar PO, Bodvarsdottir T, Antoine MH, Lebrun P, Hansen JB. Schou SC, et al. Among authors: worsaae a. Bioorg Med Chem. 2005 Jan 3;13(1):141-55. doi: 10.1016/j.bmc.2004.09.051. Bioorg Med Chem. 2005. PMID: 15582459
20 results