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Farnesyltransferase inhibitors and anti-Ras therapy.
Gibbs JB, Kohl NE, Koblan KS, Omer CA, Sepp-Lorenzino L, Rosen N, Anthony NJ, Conner MW, deSolms SJ, Williams TM, Graham SL, Hartman GD, Oliff A. Gibbs JB, et al. Among authors: conner mw. Breast Cancer Res Treat. 1996;38(1):75-83. doi: 10.1007/BF01803786. Breast Cancer Res Treat. 1996. PMID: 8825125 Review.
2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.
Williams TM, Ciccarone TM, MacTough SC, Bock RL, Conner MW, Davide JP, Hamilton K, Koblan KS, Kohl NE, Kral AM, Mosser SD, Omer CA, Pompliano DL, Rands E, Schaber MD, Shah D, Wilson FR, Gibbs JB, Graham SL, Hartman GD, Oliff AI, Smith RL. Williams TM, et al. Among authors: conner mw. J Med Chem. 1996 Mar 29;39(7):1345-8. doi: 10.1021/jm9508090. J Med Chem. 1996. PMID: 8691462 No abstract available.
Farnesyltransferase inhibitors: a new class of cancer chemotherapeutics.
Koblan KS, Kohl NE, Omer CA, Anthony NJ, Conner MW, deSolms SJ, Williams TM, Graham SL, Hartman GD, Oliff A, Gibbs JB. Koblan KS, et al. Among authors: conner mw. Biochem Soc Trans. 1996 Aug;24(3):688-92. doi: 10.1042/bst0240688. Biochem Soc Trans. 1996. PMID: 8878827 Review. No abstract available.
Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.
Omer CA, Chen Z, Diehl RE, Conner MW, Chen HY, Trumbauer ME, Gopal-Truter S, Seeburger G, Bhimnathwala H, Abrams MT, Davide JP, Ellis MS, Gibbs JB, Greenberg I, Koblan KS, Kral AM, Liu D, Lobell RB, Miller PJ, Mosser SD, O'Neill TJ, Rands E, Schaber MD, Senderak ET, Oliff A, Kohl NE. Omer CA, et al. Among authors: conner mw. Cancer Res. 2000 May 15;60(10):2680-8. Cancer Res. 2000. PMID: 10825141
A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis.
Barrington RE, Subler MA, Rands E, Omer CA, Miller PJ, Hundley JE, Koester SK, Troyer DA, Bearss DJ, Conner MW, Gibbs JB, Hamilton K, Koblan KS, Mosser SD, O'Neill TJ, Schaber MD, Senderak ET, Windle JJ, Oliff A, Kohl NE. Barrington RE, et al. Among authors: conner mw. Mol Cell Biol. 1998 Jan;18(1):85-92. doi: 10.1128/MCB.18.1.85. Mol Cell Biol. 1998. PMID: 9418856 Free PMC article.
49 results