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135 results

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Page 1
Farnesyltransferase inhibitors and anti-Ras therapy.
Gibbs JB, Kohl NE, Koblan KS, Omer CA, Sepp-Lorenzino L, Rosen N, Anthony NJ, Conner MW, deSolms SJ, Williams TM, Graham SL, Hartman GD, Oliff A. Gibbs JB, et al. Among authors: koblan ks. Breast Cancer Res Treat. 1996;38(1):75-83. doi: 10.1007/BF01803786. Breast Cancer Res Treat. 1996. PMID: 8825125 Review.
3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
Bell IM, Gallicchio SN, Abrams M, Beese LS, Beshore DC, Bhimnathwala H, Bogusky MJ, Buser CA, Culberson JC, Davide J, Ellis-Hutchings M, Fernandes C, Gibbs JB, Graham SL, Hamilton KA, Hartman GD, Heimbrook DC, Homnick CF, Huber HE, Huff JR, Kassahun K, Koblan KS, Kohl NE, Lobell RB, Lynch JJ Jr, Robinson R, Rodrigues AD, Taylor JS, Walsh ES, Williams TM, Zartman CB. Bell IM, et al. Among authors: koblan ks. J Med Chem. 2002 Jun 6;45(12):2388-409. doi: 10.1021/jm010531d. J Med Chem. 2002. PMID: 12036349
2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.
Williams TM, Ciccarone TM, MacTough SC, Bock RL, Conner MW, Davide JP, Hamilton K, Koblan KS, Kohl NE, Kral AM, Mosser SD, Omer CA, Pompliano DL, Rands E, Schaber MD, Shah D, Wilson FR, Gibbs JB, Graham SL, Hartman GD, Oliff AI, Smith RL. Williams TM, et al. Among authors: koblan ks. J Med Chem. 1996 Mar 29;39(7):1345-8. doi: 10.1021/jm9508090. J Med Chem. 1996. PMID: 8691462 No abstract available.
Farnesyltransferase inhibitors: a new class of cancer chemotherapeutics.
Koblan KS, Kohl NE, Omer CA, Anthony NJ, Conner MW, deSolms SJ, Williams TM, Graham SL, Hartman GD, Oliff A, Gibbs JB. Koblan KS, et al. Biochem Soc Trans. 1996 Aug;24(3):688-92. doi: 10.1042/bst0240688. Biochem Soc Trans. 1996. PMID: 8878827 Review. No abstract available.
Farnesyl: proteintransferase inhibitors as agents to inhibit tumor growth.
Omer CA, Anthony NJ, Buser-Doepner CA, Burkhardt AL, deSolms SJ, Dinsmore CJ, Gibbs JB, Hartman GD, Koblan KS, Lobell RB, Oliff A, Williams TM, Kohl NE. Omer CA, et al. Among authors: koblan ks. Biofactors. 1997;6(3):359-66. doi: 10.1002/biof.5520060306. Biofactors. 1997. PMID: 9288406 Review.
N-Arylalkyl pseudopeptide inhibitors of farnesyltransferase.
deSolms SJ, Giuliani EA, Graham SL, Koblan KS, Kohl NE, Mosser SD, Oliff AI, Pompliano DL, Rands E, Scholz TH, Wiscount CM, Gibbs JB, Smith RL. deSolms SJ, et al. Among authors: koblan ks. J Med Chem. 1998 Jul 2;41(14):2651-6. doi: 10.1021/jm9800907. J Med Chem. 1998. PMID: 9651171
Farnesyltransferase inhibitors versus Ras inhibitors.
Gibbs JB, Graham SL, Hartman GD, Koblan KS, Kohl NE, Omer CA, Oliff A. Gibbs JB, et al. Among authors: koblan ks. Curr Opin Chem Biol. 1997 Aug;1(2):197-203. doi: 10.1016/s1367-5931(97)80010-5. Curr Opin Chem Biol. 1997. PMID: 9667853 Review.
Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase.
Ciccarone TM, MacTough SC, Williams TM, Dinsmore CJ, O'Neill TJ, Shah D, Culberson JC, Koblan KS, Kohl NE, Gibbs JB, Oliff AI, Graham SL, Hartman GD. Ciccarone TM, et al. Among authors: koblan ks. Bioorg Med Chem Lett. 1999 Jul 19;9(14):1991-6. doi: 10.1016/s0960-894x(99)00323-6. Bioorg Med Chem Lett. 1999. PMID: 10450968
135 results