Kohl NE - Search Results

1

Farnesyltransferase inhibitors and anti-Ras therapy.

Gibbs JB, Kohl NE, Koblan KS, Omer CA, Sepp-Lorenzino L, Rosen N, Anthony NJ, Conner MW, deSolms SJ, Williams TM, Graham SL, Hartman GD, Oliff A. Gibbs JB, et al. Among authors: kohl ne. Breast Cancer Res Treat. 1996;38(1):75-83. doi: 10.1007/BF01803786. Breast Cancer Res Treat. 1996. PMID: 8825125 Review.

2

3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.

Bell IM, Gallicchio SN, Abrams M, Beese LS, Beshore DC, Bhimnathwala H, Bogusky MJ, Buser CA, Culberson JC, Davide J, Ellis-Hutchings M, Fernandes C, Gibbs JB, Graham SL, Hamilton KA, Hartman GD, Heimbrook DC, Homnick CF, Huber HE, Huff JR, Kassahun K, Koblan KS, Kohl NE, Lobell RB, Lynch JJ Jr, Robinson R, Rodrigues AD, Taylor JS, Walsh ES, Williams TM, Zartman CB. Bell IM, et al. Among authors: kohl ne. J Med Chem. 2002 Jun 6;45(12):2388-409. doi: 10.1021/jm010531d. J Med Chem. 2002. PMID: 12036349

3

Pseudodipeptide inhibitors of protein farnesyltransferase.

deSolms SJ, Deana AA, Giuliani EA, Graham SL, Kohl NE, Mosser SD, Oliff AI, Pompliano DL, Rands E, Scholz TH, et al. deSolms SJ, et al. Among authors: kohl ne. J Med Chem. 1995 Sep 29;38(20):3967-71. doi: 10.1021/jm00020a010. J Med Chem. 1995. PMID: 7562930

4

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice.

Kohl NE, Omer CA, Conner MW, Anthony NJ, Davide JP, deSolms SJ, Giuliani EA, Gomez RP, Graham SL, Hamilton K, et al. Kohl NE, et al. Nat Med. 1995 Aug;1(8):792-7. doi: 10.1038/nm0895-792. Nat Med. 1995. PMID: 7585182

5

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines.

Sepp-Lorenzino L, Ma Z, Rands E, Kohl NE, Gibbs JB, Oliff A, Rosen N. Sepp-Lorenzino L, et al. Among authors: kohl ne. Cancer Res. 1995 Nov 15;55(22):5302-9. Cancer Res. 1995. PMID: 7585592

6

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.

Kohl NE, Wilson FR, Mosser SD, Giuliani E, deSolms SJ, Conner MW, Anthony NJ, Holtz WJ, Gomez RP, Lee TJ, et al. Kohl NE, et al. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):9141-5. doi: 10.1073/pnas.91.19.9141. Proc Natl Acad Sci U S A. 1994. PMID: 8090782 Free PMC article.

7

Pseudopeptide inhibitors of Ras farnesyl-protein transferase.

Graham SL, deSolms SJ, Giuliani EA, Kohl NE, Mosser SD, Oliff AI, Pompliano DL, Rands E, Breslin MJ, Deana AA, et al. Graham SL, et al. Among authors: kohl ne. J Med Chem. 1994 Mar 18;37(6):725-32. doi: 10.1021/jm00032a004. J Med Chem. 1994. PMID: 8145221

8

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic.

Gibbs JB, Oliff A, Kohl NE. Gibbs JB, et al. Among authors: kohl ne. Cell. 1994 Apr 22;77(2):175-8. doi: 10.1016/0092-8674(94)90308-5. Cell. 1994. PMID: 8168127 Review. No abstract available.

9

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton.

Prendergast GC, Davide JP, deSolms SJ, Giuliani EA, Graham SL, Gibbs JB, Oliff A, Kohl NE. Prendergast GC, et al. Among authors: kohl ne. Mol Cell Biol. 1994 Jun;14(6):4193-202. doi: 10.1128/mcb.14.6.4193-4202.1994. Mol Cell Biol. 1994. PMID: 8196657 Free PMC article.

10

Negative growth selection against rodent fibroblasts targeted for genetic inhibition of farnesyl transferase.

Prendergast GC, Davide JP, Kral A, Diehl R, Gibbs JB, Omer CA, Kohl NE. Prendergast GC, et al. Among authors: kohl ne. Cell Growth Differ. 1993 Sep;4(9):707-13. Cell Growth Differ. 1993. PMID: 8241019

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