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In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 --> Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice.
van Vlijmen BJ, van Dijk KW, van't Hof HB, van Gorp PJ, van der Zee A, van der Boom H, Breuer ML, Hofker MH, Havekes LM. van Vlijmen BJ, et al. Among authors: breuer ml. J Biol Chem. 1996 Nov 29;271(48):30595-602. doi: 10.1074/jbc.271.48.30595. J Biol Chem. 1996. PMID: 8940032 Free article.
In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway.
Jong MC, Dahlmans VE, van Gorp PJ, van Dijk KW, Breuer ML, Hofker MH, Havekes LM. Jong MC, et al. Among authors: breuer ml. J Clin Invest. 1996 Nov 15;98(10):2259-67. doi: 10.1172/JCI119036. J Clin Invest. 1996. PMID: 8941642 Free PMC article.
Generation of transgenic mice.
Hofker MH, Breuer M. Hofker MH, et al. Methods Mol Biol. 1998;110:63-78. doi: 10.1385/1-59259-582-0:63. Methods Mol Biol. 1998. PMID: 9918039 Review. No abstract available.
Macrophage specific overexpression of the human macrophage scavenger receptor in transgenic mice, using a 180-kb yeast artificial chromosome, leads to enhanced foam cell formation of isolated peritoneal macrophages.
de Winther MP, van Dijk KW, van Vlijmen BJ, Gijbels MJ, Heus JJ, Wijers ER, van den Bos AC, Breuer M, Frants RR, Havekes LM, Hofker MH. de Winther MP, et al. Atherosclerosis. 1999 Dec;147(2):339-47. doi: 10.1016/s0021-9150(99)00204-x. Atherosclerosis. 1999. PMID: 10559520
78 results