Thurston DE - Search Results

1

Inhibition of bacteriophage T7 RNA polymerase in vitro transcription by DNA-binding pyrrolo[2,1-c][1,4]benzodiazepines.

Puvvada MS, Forrow SA, Hartley JA, Stephenson P, Gibson I, Jenkins TC, Thurston DE. Puvvada MS, et al. Among authors: thurston de. Biochemistry. 1997 Mar 4;36(9):2478-84. doi: 10.1021/bi952490r. Biochemistry. 1997. PMID: 9054552

2

Solution structure of a 2:1 C2-(2-naphthyl) pyrrolo[2,1-c][1,4]benzodiazepine DNA adduct: molecular basis for unexpectedly high DNA helix stabilization.

Antonow D, Barata T, Jenkins TC, Parkinson GN, Howard PW, Thurston DE, Zloh M. Antonow D, et al. Among authors: thurston de. Biochemistry. 2008 Nov 11;47(45):11818-29. doi: 10.1021/bi801225q. Epub 2008 Oct 17. Biochemistry. 2008. PMID: 18925745

3

A quantitative assay to measure the relative DNA-binding affinity of pyrrolo[2,1-c] [1,4]benzodiazepine (PBD) antitumour antibiotics based on the inhibition of restriction endonuclease BamHI.

Puvvada MS, Hartley JA, Jenkins TC, Thurston DE. Puvvada MS, et al. Among authors: thurston de. Nucleic Acids Res. 1993 Aug 11;21(16):3671-5. doi: 10.1093/nar/21.16.3671. Nucleic Acids Res. 1993. PMID: 8367284 Free PMC article.

4

Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers.

Smellie M, Bose DS, Thompson AS, Jenkins TC, Hartley JA, Thurston DE. Smellie M, et al. Among authors: thurston de. Biochemistry. 2003 Jul 15;42(27):8232-9. doi: 10.1021/bi034313t. Biochemistry. 2003. PMID: 12846572

5

Sequence-selective interaction of the minor-groove interstrand cross-linking agent SJG-136 with naked and cellular DNA: footprinting and enzyme inhibition studies.

Martin C, Ellis T, McGurk CJ, Jenkins TC, Hartley JA, Waring MJ, Thurston DE. Martin C, et al. Among authors: thurston de. Biochemistry. 2005 Mar 22;44(11):4135-47. doi: 10.1021/bi0479813. Biochemistry. 2005. PMID: 15766241

6

The non-covalent interaction of pyrrolo[2, 1-c] [1, 4]benzodiazepine-5, 11-diones with DNA.

Jones GB, Davey CL, Jenkins TC, Kamal A, Kneale GG, Neidle S, Webster GD, Thurston DE. Jones GB, et al. Among authors: thurston de. Anticancer Drug Des. 1990 Aug;5(3):249-64. Anticancer Drug Des. 1990. PMID: 2400538

7

Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines.

Thurston DE, Bose DS, Howard PW, Jenkins TC, Leoni A, Baraldi PG, Guiotto A, Cacciari B, Kelland LR, Foloppe MP, Rault S. Thurston DE, et al. J Med Chem. 1999 Jun 3;42(11):1951-64. doi: 10.1021/jm981117p. J Med Chem. 1999. PMID: 10354403

8

Design, synthesis, and evaluation of a novel sequence-selective epoxide-containing DNA cross-linking agent based on the pyrrolo[2, 1-c][1,4]benzodiazepine system.

Wilson SC, Howard PW, Forrow SM, Hartley JA, Adams LJ, Jenkins TC, Kelland LR, Thurston DE. Wilson SC, et al. Among authors: thurston de. J Med Chem. 1999 Oct 7;42(20):4028-41. doi: 10.1021/jm981124d. J Med Chem. 1999. PMID: 10514273

9

Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines.

Gregson SJ, Howard PW, Corcoran KE, Barcella S, Yasin MM, Hurst AA, Jenkins TC, Kelland LR, Thurston DE. Gregson SJ, et al. Among authors: thurston de. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1845-7. doi: 10.1016/s0960-894x(00)00351-6. Bioorg Med Chem Lett. 2000. PMID: 10969982

10

Effect of C2/C3-endo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines.

Gregson SJ, Howard PW, Barcella S, Nakamya A, Jenkins TC, Kelland LR, Thurston DE. Gregson SJ, et al. Among authors: thurston de. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1849-51. doi: 10.1016/s0960-894x(00)00350-4. Bioorg Med Chem Lett. 2000. PMID: 10969983

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