A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains.
Martens E, Leyssen A, Van Aelst I, Fiten P, Piccard H, Hu J, Descamps FJ, Van den Steen PE, Proost P, Van Damme J, Liuzzi GM, Riccio P, Polverini E, Opdenakker G.
Martens E, et al. Among authors: van den steen pe, van damme j, van aelst i.
Biochim Biophys Acta. 2007 Feb;1770(2):178-86. doi: 10.1016/j.bbagen.2006.10.012. Epub 2006 Oct 26.
Biochim Biophys Acta. 2007.
PMID: 17137715