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L-tryptophan urea amides as NK1/NK2 dual antagonists.
Qi H, Shah SK, Cascieri MA, Sadowski SJ, MaCcoss M. Qi H, et al. Among authors: sadowski sj. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2259-62. doi: 10.1016/s0960-894x(98)00395-3. Bioorg Med Chem Lett. 1998. PMID: 9873524
Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor.
Cascieri MA, Macleod AM, Underwood D, Shiao LL, Ber E, Sadowski S, Yu H, Merchant KJ, Swain CJ, Strader CD, et al. Cascieri MA, et al. Among authors: sadowski s. J Biol Chem. 1994 Mar 4;269(9):6587-91. J Biol Chem. 1994. PMID: 7509807 Free article.
M., Merchant, K. J., Cascieri, M. A., Sadowski, S., Ber, E., Swain, C. J., and Baker, R. (1993) J. Med Chem. 14, 2044-2045). We now report the detailed characterization of the interaction of N-acetyl-L-tryptophan-3,5-bistrifluoromethyl benzyl ester (L-732,138) with …
M., Merchant, K. J., Cascieri, M. A., Sadowski, S., Ber, E., Swain, C. J., and Baker, R. (1993) J. Med Chem. 14, 2044-2045). W …
2(S)-((3,5-bis(trifluoromethyl)benzyl)-oxy)-3(S)-phenyl-4- ((3-oxo-1,2,4-triazol-5-yl)methyl)morpholine (1): a potent, orally active, morpholine-based human neurokinin-1 receptor antagonist.
Hale JJ, Mills SG, MacCoss M, Shah SK, Qi H, Mathre DJ, Cascieri MA, Sadowski S, Strader CD, MacIntyre DE, Metzger JM. Hale JJ, et al. Among authors: sadowski s. J Med Chem. 1996 Apr 26;39(9):1760-2. doi: 10.1021/jm950654w. J Med Chem. 1996. PMID: 8627597 No abstract available.
162 results