Lima WF - Search Results

1

The influence of antisense oligonucleotide-induced RNA structure on Escherichia coli RNase H1 activity.

Lima WF, Mohan V, Crooke ST. Lima WF, et al. J Biol Chem. 1997 Jul 18;272(29):18191-9. doi: 10.1074/jbc.272.29.18191. J Biol Chem. 1997. PMID: 9218455 Free article.

2

Human RNase H1 activity is regulated by a unique redox switch formed between adjacent cysteines.

Lima WF, Wu H, Nichols JG, Manalili SM, Drader JJ, Hofstadler SA, Crooke ST. Lima WF, et al. J Biol Chem. 2003 Apr 25;278(17):14906-12. doi: 10.1074/jbc.M211279200. Epub 2002 Dec 8. J Biol Chem. 2003. PMID: 12473655 Free article.

3

Human RNase H1 uses one tryptophan and two lysines to position the enzyme at the 3'-DNA/5'-RNA terminus of the heteroduplex substrate.

Lima WF, Wu H, Nichols JG, Prakash TP, Ravikumar V, Crooke ST. Lima WF, et al. J Biol Chem. 2003 Dec 12;278(50):49860-7. doi: 10.1074/jbc.M306543200. Epub 2003 Sep 23. J Biol Chem. 2003. PMID: 14506260 Free article.

4

Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs.

Wu H, Lima WF, Zhang H, Fan A, Sun H, Crooke ST. Wu H, et al. Among authors: lima wf. J Biol Chem. 2004 Apr 23;279(17):17181-9. doi: 10.1074/jbc.M311683200. Epub 2004 Feb 11. J Biol Chem. 2004. PMID: 14960586 Free article.

5

Structural requirements at the catalytic site of the heteroduplex substrate for human RNase H1 catalysis.

Lima WF, Nichols JG, Wu H, Prakash TP, Migawa MT, Wyrzykiewicz TK, Bhat B, Crooke ST. Lima WF, et al. J Biol Chem. 2004 Aug 27;279(35):36317-26. doi: 10.1074/jbc.M405035200. Epub 2004 Jun 17. J Biol Chem. 2004. PMID: 15205459 Free article.

6

The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis.

Lima WF, Rose JB, Nichols JG, Wu H, Migawa MT, Wyrzykiewicz TK, Vasquez G, Swayze EE, Crooke ST. Lima WF, et al. Mol Pharmacol. 2007 Jan;71(1):73-82. doi: 10.1124/mol.106.025429. Epub 2006 Oct 6. Mol Pharmacol. 2007. PMID: 17028157

7

Human RNase H1 discriminates between subtle variations in the structure of the heteroduplex substrate.

Lima WF, Rose JB, Nichols JG, Wu H, Migawa MT, Wyrzykiewicz TK, Siwkowski AM, Crooke ST. Lima WF, et al. Mol Pharmacol. 2007 Jan;71(1):83-91. doi: 10.1124/mol.106.025015. Epub 2006 Oct 6. Mol Pharmacol. 2007. PMID: 17028158

8

Human Dicer binds short single-strand and double-strand RNA with high affinity and interacts with different regions of the nucleic acids.

Lima WF, Murray H, Nichols JG, Wu H, Sun H, Prakash TP, Berdeja AR, Gaus HJ, Crooke ST. Lima WF, et al. J Biol Chem. 2009 Jan 23;284(4):2535-48. doi: 10.1074/jbc.M803748200. Epub 2008 Nov 18. J Biol Chem. 2009. PMID: 19017633 Free article.

9

Binding and cleavage specificities of human Argonaute2.

Lima WF, Wu H, Nichols JG, Sun H, Murray HM, Crooke ST. Lima WF, et al. J Biol Chem. 2009 Sep 18;284(38):26017-28. doi: 10.1074/jbc.M109.010835. Epub 2009 Jul 22. J Biol Chem. 2009. PMID: 19625255 Free PMC article.

10

Defining the factors that contribute to on-target specificity of antisense oligonucleotides.

Lima WF, Vickers TA, Nichols J, Li C, Crooke ST. Lima WF, et al. PLoS One. 2014 Jul 29;9(7):e101752. doi: 10.1371/journal.pone.0101752. eCollection 2014. PLoS One. 2014. PMID: 25072142 Free PMC article.

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