Chapman KL - Search Results

1

5-(Piperidin-2-yl)- and 5-(homopiperidin-2-yl)-1,4-benzodiazepines: high-affinity, basic ligands for the cholecystokinin-B receptor.

Castro JL, Broughton HB, Russell MG, Rathbone D, Watt AP, Ball RG, Chapman KL, Patel S, Smith AJ, Marshall GR, Matassa VG. Castro JL, et al. Among authors: chapman kl. J Med Chem. 1997 Aug 1;40(16):2491-501. doi: 10.1021/jm9608523. J Med Chem. 1997. PMID: 9258356

2

A second generation of non-peptide cholecystokinin receptor antagonists and their possible therapeutic potential.

Freedman SB, Patel S, Smith AJ, Chapman K, Fletcher A, Kemp JA, Marshall GR, Hargreaves RJ, Scholey K, Mellin EC, et al. Freedman SB, et al. Ann N Y Acad Sci. 1994 Mar 23;713:312-8. doi: 10.1111/j.1749-6632.1994.tb44079.x. Ann N Y Acad Sci. 1994. PMID: 8185173 Review.

3

Selective non-peptide ligands for an accommodating peptide receptor. Imidazobenzodiazepines as potent cholecystokinin type B receptor antagonists.

Bock MG, DiPardo RM, Newton RC, Bergman JM, Veber DF, Freedman SB, Smith AJ, Chapman KL, Patel S, Kemp JA, et al. Bock MG, et al. Among authors: chapman kl. Bioorg Med Chem. 1994 Sep;2(9):987-98. doi: 10.1016/s0968-0896(00)82047-7. Bioorg Med Chem. 1994. PMID: 7712133

4

Biological properties of the benzodiazepine amidine derivative L-740,093, a cholecystokinin-B/gastrin receptor antagonist with high affinity in vitro and high potency in vivo.

Patel S, Smith AJ, Chapman KL, Fletcher AE, Kemp JA, Marshall GR, Hargreaves RJ, Ryecroft W, Iversen LL, Iversen SD, et al. Patel S, et al. Among authors: chapman kl. Mol Pharmacol. 1994 Nov;46(5):943-8. Mol Pharmacol. 1994. PMID: 7969084

5

Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas.

Castro JL, Ball RG, Broughton HB, Russell MG, Rathbone D, Watt AP, Baker R, Chapman KL, Fletcher AE, Patel S, Smith AJ, Marshall GR, Ryecroft W, Matassa VG. Castro JL, et al. Among authors: chapman kl. J Med Chem. 1996 Feb 16;39(4):842-9. doi: 10.1021/jm9506736. J Med Chem. 1996. PMID: 8632408

6

Are radioligand antagonist/agonist binding ratios in rat pancreas predictive of functional efficacy of cholecystokinin receptor agonists and antagonists?

Patel S, Chapman KL, Smith AJ, Bailey I, Freedman SB. Patel S, et al. Among authors: chapman kl. Regul Pept. 1996 Aug 27;65(1):29-35. doi: 10.1016/0167-0115(96)00069-9. Regul Pept. 1996. PMID: 8876033

7

4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.

Fletcher SR, Burkamp F, Blurton P, Cheng SK, Clarkson R, O'Connor D, Spinks D, Tudge M, van Niel MB, Patel S, Chapman K, Marwood R, Shepheard S, Bentley G, Cook GP, Bristow LJ, Castro JL, Hutson PH, MacLeod AM. Fletcher SR, et al. J Med Chem. 2002 Jan 17;45(2):492-503. doi: 10.1021/jm011030v. J Med Chem. 2002. PMID: 11784153

8

A new class of selective, non-basic 5-HT2A receptor antagonists.

Ladduwahetty T, Boase AL, Mitchinson A, Quin C, Patel S, Chapman K, MacLeod AM. Ladduwahetty T, et al. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3201-4. doi: 10.1016/j.bmcl.2006.03.050. Epub 2006 May 2. Bioorg Med Chem Lett. 2006. PMID: 16632354

9

Use of ex vivo binding to estimate brain penetration and central activity of CCK-B antagonists.

Patel S, Chapman KL, Smith AJ, Heald A, Freedman SB. Patel S, et al. Among authors: chapman kl. Ann N Y Acad Sci. 1994 Mar 23;713:360-3. doi: 10.1111/j.1749-6632.1994.tb44093.x. Ann N Y Acad Sci. 1994. PMID: 8185188 No abstract available.

10

Measurement of central nervous system activity of systemically administered CCKB receptor antagonists by ex vivo binding.

Patel S, Chapman KL, Heald A, Smith AJ, Freedman SB. Patel S, et al. Among authors: chapman kl. Eur J Pharmacol. 1994 Mar 3;253(3):237-44. doi: 10.1016/0014-2999(94)90197-x. Eur J Pharmacol. 1994. PMID: 8200418

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