Paonessa G - Search Results

1

Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist.

Ciapponi L, Maione D, Scoumanne A, Costa P, Hansen MB, Svenson M, Bendtzen K, Alonzi T, Paonessa G, Cortese R, Ciliberto G, Savino R. Ciapponi L, et al. Among authors: paonessa g. Nat Biotechnol. 1997 Oct;15(10):997-1001. doi: 10.1038/nbt1097-997. Nat Biotechnol. 1997. PMID: 9335053

2

Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.

Savino R, Lahm A, Salvati AL, Ciapponi L, Sporeno E, Altamura S, Paonessa G, Toniatti C, Ciliberto G. Savino R, et al. Among authors: paonessa g. EMBO J. 1994 Mar 15;13(6):1357-67. doi: 10.1002/j.1460-2075.1994.tb06389.x. EMBO J. 1994. PMID: 7511100 Free PMC article.

3

The molecular design of human IL-6 receptor antagonists.

Lahm A, Savino R, Salvati AL, Cabibbo A, Ciapponi L, Demartis A, Toniatti C, Paonessa G, Altamura S, Ciliberto G. Lahm A, et al. Among authors: paonessa g. Ann N Y Acad Sci. 1995 Jul 21;762:136-50; discussion 150-1. doi: 10.1111/j.1749-6632.1995.tb32322.x. Ann N Y Acad Sci. 1995. PMID: 7668525 No abstract available.

4

Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.

Paonessa G, Graziani R, De Serio A, Savino R, Ciapponi L, Lahm A, Salvati AL, Toniatti C, Ciliberto G. Paonessa G, et al. EMBO J. 1995 May 1;14(9):1942-51. doi: 10.1002/j.1460-2075.1995.tb07186.x. EMBO J. 1995. PMID: 7744001 Free PMC article.

5

Interleukin-6 (IL-6) antagonism by soluble IL-6 receptor alpha mutated in the predicted gp130-binding interface.

Salvati AL, Lahm A, Paonessa G, Ciliberto G, Toniatti C. Salvati AL, et al. Among authors: paonessa g. J Biol Chem. 1995 May 19;270(20):12242-9. doi: 10.1074/jbc.270.20.12242. J Biol Chem. 1995. PMID: 7744875 Free article.

6

Definition of a composite binding site for gp130 in human interleukin-6.

Ciapponi L, Graziani R, Paonessa G, Lahm A, Ciliberto G, Savino R. Ciapponi L, et al. Among authors: paonessa g. J Biol Chem. 1995 Dec 29;270(52):31249-54. doi: 10.1074/jbc.270.52.31249. J Biol Chem. 1995. PMID: 8537391 Free article.

7

Monovalent phage display of human interleukin (hIL)-6: selection of superbinder variants from a complex molecular repertoire in the hIL-6 D-helix.

Cabibbo A, Sporeno E, Toniatti C, Altamura S, Savino R, Paonessa G, Ciliberto G. Cabibbo A, et al. Among authors: paonessa g. Gene. 1995 Dec 29;167(1-2):41-7. doi: 10.1016/0378-1119(95)00632-x. Gene. 1995. PMID: 8566809

8

Human interleukin-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells.

Sporeno E, Savino R, Ciapponi L, Paonessa G, Cabibbo A, Lahm A, Pulkki K, Sun RX, Toniatti C, Klein B, Ciliberto G. Sporeno E, et al. Among authors: paonessa g. Blood. 1996 Jun 1;87(11):4510-9. Blood. 1996. PMID: 8639818 Free article.

9

Functional expression of soluble human interleukin-11 (IL-11) receptor alpha and stoichiometry of in vitro IL-11 receptor complexes with gp130.

Neddermann P, Graziani R, Ciliberto G, Paonessa G. Neddermann P, et al. Among authors: paonessa g. J Biol Chem. 1996 Nov 29;271(48):30986-91. doi: 10.1074/jbc.271.48.30986. J Biol Chem. 1996. PMID: 8940087 Free article.

10

Oncostatin M binds directly to gp130 and behaves as interleukin-6 antagonist on a cell line expressing gp130 but lacking functional oncostatin M receptors.

Sporeno E, Paonessa G, Salvati AL, Graziani R, Delmastro P, Ciliberto G, Toniatti C. Sporeno E, et al. Among authors: paonessa g. J Biol Chem. 1994 Apr 15;269(15):10991-5. J Biol Chem. 1994. PMID: 8157624 Free article.

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