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ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site.
Hussain I, Powell DJ, Howlett DR, Chapman GA, Gilmour L, Murdock PR, Tew DG, Meek TD, Chapman C, Schneider K, Ratcliffe SJ, Tattersall D, Testa TT, Southan C, Ryan DM, Simmons DL, Walsh FS, Dingwall C, Christie G. Hussain I, et al. Among authors: christie g. Mol Cell Neurosci. 2000 Nov;16(5):609-19. doi: 10.1006/mcne.2000.0884. Mol Cell Neurosci. 2000. PMID: 11083922
Presenilins--in search of functionality.
Karran EH, Allsop D, Christie G, Davis J, Gray C, Mansfield F, Ward RV. Karran EH, et al. Among authors: christie g. Biochem Soc Trans. 1998 Aug;26(3):491-6. doi: 10.1042/bst0260491. Biochem Soc Trans. 1998. PMID: 9765902 Review.
Fibrillogenesis of beta-amyloid.
Allsop D, Howlett D, Christie G, Karran E. Allsop D, et al. Among authors: christie g. Biochem Soc Trans. 1998 Aug;26(3):459-63. doi: 10.1042/bst0260459. Biochem Soc Trans. 1998. PMID: 9765896 Review. No abstract available.
Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.
Christie G, Markwell RE, Gray CW, Smith L, Godfrey F, Mansfield F, Wadsworth H, King R, McLaughlin M, Cooper DG, Ward RV, Howlett DR, Hartmann T, Lichtenthaler SF, Beyreuther K, Underwood J, Gribble SK, Cappai R, Masters CL, Tamaoka A, Gardner RL, Rivett AJ, Karran EH, Allsop D. Christie G, et al. J Neurochem. 1999 Jul;73(1):195-204. doi: 10.1046/j.1471-4159.1999.0730195.x. J Neurochem. 1999. PMID: 10386971 Free article.
Inhibitor of neurite outgrowth in humans.
Prinjha R, Moore SE, Vinson M, Blake S, Morrow R, Christie G, Michalovich D, Simmons DL, Walsh FS. Prinjha R, et al. Among authors: christie g. Nature. 2000 Jan 27;403(6768):383-4. doi: 10.1038/35000287. Nature. 2000. PMID: 10667780 No abstract available.
397 results