Harrison NL - Search Results

1

Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane.

Krasowski MD, Koltchine VV, Rick CE, Ye Q, Finn SE, Harrison NL. Krasowski MD, et al. Among authors: harrison nl. Mol Pharmacol. 1998 Mar;53(3):530-8. doi: 10.1124/mol.53.3.530. Mol Pharmacol. 1998. PMID: 9495821

2

Trichloroethanol modulation of recombinant GABAA, glycine and GABA rho 1 receptors.

Krasowski MD, Finn SE, Ye Q, Harrison NL. Krasowski MD, et al. Among authors: harrison nl. J Pharmacol Exp Ther. 1998 Mar;284(3):934-42. J Pharmacol Exp Ther. 1998. PMID: 9495852

3

Agonist gating and isoflurane potentiation in the human gamma-aminobutyric acid type A receptor determined by the volume of a second transmembrane domain residue.

Koltchine VV, Finn SE, Jenkins A, Nikolaeva N, Lin A, Harrison NL. Koltchine VV, et al. Among authors: harrison nl. Mol Pharmacol. 1999 Nov;56(5):1087-93. doi: 10.1124/mol.56.5.1087. Mol Pharmacol. 1999. PMID: 10531417

4

The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations.

Krasowski MD, Harrison NL. Krasowski MD, et al. Among authors: harrison nl. Br J Pharmacol. 2000 Feb;129(4):731-43. doi: 10.1038/sj.bjp.0703087. Br J Pharmacol. 2000. PMID: 10683198 Free PMC article.

5

General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor but not with lipid solubility.

Krasowski MD, Jenkins A, Flood P, Kung AY, Hopfinger AJ, Harrison NL. Krasowski MD, et al. Among authors: harrison nl. J Pharmacol Exp Ther. 2001 Apr;297(1):338-51. J Pharmacol Exp Ther. 2001. PMID: 11259561

6

Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics.

Krasowski MD, Nishikawa K, Nikolaeva N, Lin A, Harrison NL. Krasowski MD, et al. Among authors: harrison nl. Neuropharmacology. 2001 Dec;41(8):952-64. doi: 10.1016/s0028-3908(01)00141-1. Neuropharmacology. 2001. PMID: 11747900 Free PMC article.

7

Alpha subunit isoform influences GABA(A) receptor modulation by propofol.

Krasowski MD, O'Shea SM, Rick CE, Whiting PJ, Hadingham KL, Czajkowski C, Harrison NL. Krasowski MD, et al. Among authors: harrison nl. Neuropharmacology. 1997 Jul;36(7):941-9. doi: 10.1016/s0028-3908(97)00074-9. Neuropharmacology. 1997. PMID: 9257938 Free PMC article.

8

4D-QSAR analysis of a set of propofol analogues: mapping binding sites for an anesthetic phenol on the GABA(A) receptor.

Krasowski MD, Hong X, Hopfinger AJ, Harrison NL. Krasowski MD, et al. Among authors: harrison nl. J Med Chem. 2002 Jul 18;45(15):3210-21. doi: 10.1021/jm010461a. J Med Chem. 2002. PMID: 12109905 Free PMC article.

9

A deficit of functional GABA(A) receptors in neurons of beta 3 subunit knockout mice.

Krasowski MD, Rick CE, Harrison NL, Firestone LL, Homanics GE. Krasowski MD, et al. Among authors: harrison nl. Neurosci Lett. 1998 Jan 9;240(2):81-4. doi: 10.1016/s0304-3940(97)00929-4. Neurosci Lett. 1998. PMID: 9486477 Free PMC article.

10

Neurosteroids act on the GABA(A) receptor at sites on the N-terminal side of the middle of TM2.

Rick CE, Ye Q, Finn SE, Harrison NL. Rick CE, et al. Among authors: harrison nl. Neuroreport. 1998 Feb 16;9(3):379-83. doi: 10.1097/00001756-199802160-00004. Neuroreport. 1998. PMID: 9512375

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