Hatse S - Search Results

1

Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers.

Annaert P, Gosselin G, Pompon A, Benzaria S, Valette G, Imbach JL, Naesens L, Hatse S, de Clercq E, Van den Mooter G, Kinget R, Augustijns P. Annaert P, et al. Among authors: hatse s. Pharm Res. 1998 Feb;15(2):239-45. doi: 10.1023/a:1011914618109. Pharm Res. 1998. PMID: 9523310

2

Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).

Balzarini J, Hatse S, Naesens L, De Clercq E. Balzarini J, et al. Among authors: hatse s. Biochim Biophys Acta. 1998 Mar 12;1402(1):29-38. doi: 10.1016/s0167-4889(97)00143-2. Biochim Biophys Acta. 1998. PMID: 9551083 Free article.

3

Evidence for distinction of the differentiation-inducing activities and cytostatic properties of 9-(2-phosphonylmethoxyethyl)adenine and a variety of differentiation-inducing agents in human erythroleukemia K562 cells.

Hatse S, De Clercq E, Balzarini J. Hatse S, et al. Mol Pharmacol. 1996 Nov;50(5):1231-42. Mol Pharmacol. 1996. PMID: 8913355

4

Potent antitumor activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine in choriocarcinoma-bearing rats.

Hatse S, Naesens L, Degrève B, Segers C, Vandeputte M, Waer M, De Clercq E, Balzarini J. Hatse S, et al. Int J Cancer. 1998 May 18;76(4):595-600. doi: 10.1002/(sici)1097-0215(19980518)76:4<595::aid-ijc24>3.0.co;2-5. Int J Cancer. 1998. PMID: 9590139

5

In vitro and in vivo inhibitory activity of the differentiation-inducing agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against rat choriocarcinoma.

Hatse S, Naesens L, Degrève B, Vandeputte M, Waer M, De Clercq E, Balzarini J. Hatse S, et al. Adv Exp Med Biol. 1998;431:605-9. doi: 10.1007/978-1-4615-5381-6_117. Adv Exp Med Biol. 1998. PMID: 9598137

6

Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model.

Hatse S, Naesens L, De Clercq E, Balzarini J. Hatse S, et al. Biochem Pharmacol. 1998 Oct 1;56(7):851-9. doi: 10.1016/s0006-2952(98)00058-6. Biochem Pharmacol. 1998. PMID: 9774147

7

Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.

Hatse S, De Clercq E, Balzarini J. Hatse S, et al. Mol Pharmacol. 1998 Nov;54(5):907-17. doi: 10.1124/mol.54.5.907. Mol Pharmacol. 1998. PMID: 9804626

8

Impact of 9-(2-phosphonylmethoxyethyl)adenine on (deoxy)ribonucleotide metabolism and nucleic acid synthesis in tumor cells.

Hatse S, De Clercq E, Balzarini J. Hatse S, et al. FEBS Lett. 1999 Feb 19;445(1):92-7. doi: 10.1016/s0014-5793(99)00104-0. FEBS Lett. 1999. PMID: 10069380 Free article.

9

9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine: a novel prodrug of 9-(2-phosphonylmethoxyethyl)guanine with improved antitumor efficacy and selectivity in choriocarcinoma-bearing rats.

Naesens L, Hatse S, Segers C, Verbeken E, De Clercq E, Waer M, Balzarini J. Naesens L, et al. Among authors: hatse s. Oncol Res. 1999;11(4):195-203. Oncol Res. 1999. PMID: 10566618

10

The human immunodeficiency virus(HIV) inhibitor 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a strong inducer of differentiation of several tumor cell lines.

Balzarini J, Verstuyf A, Hatse S, Goebels J, Sobis H, Vandeputte M, De Clercq E. Balzarini J, et al. Among authors: hatse s. Int J Cancer. 1995 Mar 29;61(1):130-7. doi: 10.1002/ijc.2910610122. Int J Cancer. 1995. PMID: 7705926

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