Naesens L - Search Results

1

Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers.

Annaert P, Gosselin G, Pompon A, Benzaria S, Valette G, Imbach JL, Naesens L, Hatse S, de Clercq E, Van den Mooter G, Kinget R, Augustijns P. Annaert P, et al. Among authors: naesens l. Pharm Res. 1998 Feb;15(2):239-45. doi: 10.1023/a:1011914618109. Pharm Res. 1998. PMID: 9523310

2

Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2).

Annaert P, Kinget R, Naesens L, de Clercq E, Augustijns P. Annaert P, et al. Among authors: naesens l. Pharm Res. 1997 Apr;14(4):492-6. doi: 10.1023/a:1012155717819. Pharm Res. 1997. PMID: 9144737

3

Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).

Balzarini J, Hatse S, Naesens L, De Clercq E. Balzarini J, et al. Among authors: naesens l. Biochim Biophys Acta. 1998 Mar 12;1402(1):29-38. doi: 10.1016/s0167-4889(97)00143-2. Biochim Biophys Acta. 1998. PMID: 9551083 Free article.

4

Carrier mechanisms involved in the transepithelial transport of bis(POM)-PMEA and its metabolites across Caco-2 monolayers.

Annaert P, Van Gelder J, Naesens L, De Clercq E, Van den Mooter G, Kinget R, Augustijns P. Annaert P, et al. Among authors: naesens l. Pharm Res. 1998 Aug;15(8):1168-73. doi: 10.1023/a:1011923420719. Pharm Res. 1998. PMID: 9706045

5

Stability of UC-781, in intestinal mucosal homogenates of the rat, rabbit, and pig.

Van den Mooter G, Stas G, Damian F, Naesens L, Balzarini J, Kinget R, Augustijns P. Van den Mooter G, et al. Among authors: naesens l. Pharm Res. 1998 Nov;15(11):1799-802. doi: 10.1023/a:1011985418360. Pharm Res. 1998. PMID: 9834007 No abstract available.

6

Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study.

Van Gelder J, Annaert P, Naesens L, De Clercq E, Van den Mooter G, Kinget R, Augustijns P. Van Gelder J, et al. Among authors: naesens l. Pharm Res. 1999 Jul;16(7):1035-40. doi: 10.1023/a:1018931631912. Pharm Res. 1999. PMID: 10450927

7

In vitro, ex vivo, and in situ intestinal absorption characteristics of the antiviral ester prodrug adefovir dipivoxil.

Annaert P, Tukker JJ, van Gelder J, Naesens L, de Clercq E, van Den Mooter G, Kinget R, Augustijns P. Annaert P, et al. Among authors: naesens l. J Pharm Sci. 2000 Aug;89(8):1054-62. doi: 10.1002/1520-6017(200008)89:8<1054::aid-jps10>3.0.co;2-5. J Pharm Sci. 2000. PMID: 10906729

8

Increased absorption of the antiviral ester prodrug tenofovir disoproxil in rat ileum by inhibiting its intestinal metabolism.

Van Gelder J, Deferme S, Annaert P, Naesens L, De Clercq E, Van den Mooter G, Kinget R, Augustijns P. Van Gelder J, et al. Among authors: naesens l. Drug Metab Dispos. 2000 Dec;28(12):1394-6. Drug Metab Dispos. 2000. PMID: 11095573

9

Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures.

van Gelder J, Deferme S, Naesens L, De Clercq E, van den Mooter G, Kinget R, Augustijns P. van Gelder J, et al. Among authors: naesens l. Drug Metab Dispos. 2002 Aug;30(8):924-30. doi: 10.1124/dmd.30.8.924. Drug Metab Dispos. 2002. PMID: 12124311

10

Pharmacokinetics in mice of the anti-retrovirus agent 9-(2-phosphonylmethoxyethyl)adenine.

Naesens L, Balzarini J, De Clercq E. Naesens L, et al. Drug Metab Dispos. 1992 Sep-Oct;20(5):747-52. Drug Metab Dispos. 1992. PMID: 1358582

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