Chen Z - Search Results

1

Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form.

Yan Y, Li Y, Munshi S, Sardana V, Cole JL, Sardana M, Steinkuehler C, Tomei L, De Francesco R, Kuo LC, Chen Z. Yan Y, et al. Among authors: chen z. Protein Sci. 1998 Apr;7(4):837-47. doi: 10.1002/pro.5560070402. Protein Sci. 1998. PMID: 9568891 Free PMC article.

2

X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)--an initial glance of the viral DNA binding platform.

Chen Z, Yan Y, Munshi S, Li Y, Zugay-Murphy J, Xu B, Witmer M, Felock P, Wolfe A, Sardana V, Emini EA, Hazuda D, Kuo LC. Chen Z, et al. J Mol Biol. 2000 Feb 18;296(2):521-33. doi: 10.1006/jmbi.1999.3451. J Mol Biol. 2000. PMID: 10669606

3

Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases.

Coburn CA, Stachel SJ, Li YM, Rush DM, Steele TG, Chen-Dodson E, Holloway MK, Xu M, Huang Q, Lai MT, DiMuzio J, Crouthamel MC, Shi XP, Sardana V, Chen Z, Munshi S, Kuo L, Makara GM, Annis DA, Tadikonda PK, Nash HM, Vacca JP, Wang T. Coburn CA, et al. Among authors: chen z, chen dodson e. J Med Chem. 2004 Dec 2;47(25):6117-9. doi: 10.1021/jm049388p. J Med Chem. 2004. PMID: 15566281

4

A general procedure for the purification of human beta-secretase expressed in Escherichia coli.

Sardana V, Xu B, Zugay-Murphy J, Chen Z, Sardana M, Darke PL, Munshi S, Kuo LC. Sardana V, et al. Among authors: chen z. Protein Expr Purif. 2004 Apr;34(2):190-6. doi: 10.1016/j.pep.2003.12.014. Protein Expr Purif. 2004. PMID: 15003250

5

Crystal structure of human alpha-thrombin complexed with hirugen and p-amidinophenylpyruvate at 1.6 A resolution.

Chen Z, Li Y, Mulichak AM, Lewis SD, Shafer JA. Chen Z, et al. Arch Biochem Biophys. 1995 Sep 10;322(1):198-203. doi: 10.1006/abbi.1995.1452. Arch Biochem Biophys. 1995. PMID: 7574675

6

Three-dimensional structure of a mutant HIV-1 protease displaying cross-resistance to all protease inhibitors in clinical trials.

Chen Z, Li Y, Schock HB, Hall D, Chen E, Kuo LC. Chen Z, et al. Among authors: chen e. J Biol Chem. 1995 Sep 15;270(37):21433-6. doi: 10.1074/jbc.270.37.21433. J Biol Chem. 1995. PMID: 7665551 Free article.

These structures are compared with those of the wild-type enzyme and its complex with MK639 (Chen, Z., Li, Y., Chen, E., Hall, D. L., Darke, P. L., Culberson, C., Shafer, J., and Kuo, L. ...

These structures are compared with those of the wild-type enzyme and its complex with MK639 (Chen, Z., Li, Y., Chen, E. …

7

Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases.

Chen Z, Li Y, Chen E, Hall DL, Darke PL, Culberson C, Shafer JA, Kuo LC. Chen Z, et al. Among authors: chen e. J Biol Chem. 1994 Oct 21;269(42):26344-8. J Biol Chem. 1994. PMID: 7929352 Free article.

8

Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme.

Munshi S, Chen Z, Li Y, Olsen DB, Fraley ME, Hungate RW, Kuo LC. Munshi S, et al. Among authors: chen z. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):1053-60. doi: 10.1107/s0907444998003588. Acta Crystallogr D Biol Crystallogr. 1998. PMID: 9757136

9

Purification, solution properties and crystallization of SIV integrase containing a continuous core and C-terminal domain.

Li Y, Yan Y, Zugay-Murphy J, Xu B, Cole JL, Witmer M, Felock P, Wolfe A, Hazuda D, Sardana MK, Chen Z, Kuo LC, Sardana VV. Li Y, et al. Among authors: chen z. Acta Crystallogr D Biol Crystallogr. 1999 Nov;55(Pt 11):1906-10. doi: 10.1107/s0907444999009610. Acta Crystallogr D Biol Crystallogr. 1999. PMID: 10531491

10

An alternate binding site for the P1-P3 group of a class of potent HIV-1 protease inhibitors as a result of concerted structural change in the 80s loop of the protease.

Munshi S, Chen Z, Yan Y, Li Y, Olsen DB, Schock HB, Galvin BB, Dorsey B, Kuo LC. Munshi S, et al. Among authors: chen z. Acta Crystallogr D Biol Crystallogr. 2000 Apr;56(Pt 4):381-8. doi: 10.1107/s0907444900000469. Acta Crystallogr D Biol Crystallogr. 2000. PMID: 10739910

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