Forbes IT - Search Results

1

Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines.

Bromidge SM, Dabbs S, Davies DT, Duckworth DM, Forbes IT, Ham P, Jones GE, King FD, Saunders DV, Starr S, Thewlis KM, Wyman PA, Blaney FE, Naylor CB, Bailey F, Blackburn TP, Holland V, Kennett GA, Riley GJ, Wood MD. Bromidge SM, et al. Among authors: forbes it. J Med Chem. 1998 May 7;41(10):1598-612. doi: 10.1021/jm970741j. J Med Chem. 1998. PMID: 9572885

2

Identification of a novel series of selective 5-HT7 receptor antagonists.

Forbes IT, Cooper DG, Dodds EK, Douglas SE, Gribble AD, Ife RJ, Lightfoot AP, Meeson M, Campbell LP, Coleman T, Riley GJ, Thomas DR. Forbes IT, et al. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1055-8. doi: 10.1016/s0960-894x(03)00077-5. Bioorg Med Chem Lett. 2003. PMID: 12643910

3

In vivo properties of SB 200646A, a 5-HT2C/2B receptor antagonist.

Kennett GA, Wood MD, Glen A, Grewal S, Forbes I, Gadre A, Blackburn TP. Kennett GA, et al. Br J Pharmacol. 1994 Mar;111(3):797-802. doi: 10.1111/j.1476-5381.1994.tb14808.x. Br J Pharmacol. 1994. PMID: 7912626 Free PMC article.

4

Synthesis and evaluation of a series of aryl[e]fused pyrazolo[4,3-c]pyridines with potential anxiolytic activity.

Forbes IT, Johnson CN, Jones GE, Loudon J, Nicholass JM, Thompson M, Upton N. Forbes IT, et al. J Med Chem. 1990 Sep;33(9):2640-5. doi: 10.1021/jm00171a046. J Med Chem. 1990. PMID: 1975276

5

5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel 5-HT2C/5-HT2B receptor antagonist with improved affinity, selectivity, and oral activity.

Forbes IT, Ham P, Booth DH, Martin RT, Thompson M, Baxter GS, Blackburn TP, Glen A, Kennett GA, Wood MD. Forbes IT, et al. J Med Chem. 1995 Jul 7;38(14):2524-30. doi: 10.1021/jm00014a004. J Med Chem. 1995. PMID: 7629791

6

N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity 5-HT2B receptor antagonist.

Forbes IT, Jones GE, Murphy OE, Holland V, Baxter GS. Forbes IT, et al. J Med Chem. 1995 Mar 17;38(6):855-7. doi: 10.1021/jm00006a001. J Med Chem. 1995. PMID: 7699699 No abstract available.

7

N-(1-methyl-5-indolyl)-N'-(3-pyridyl)urea hydrochloride: the first selective 5-HT1C receptor antagonist.

Forbes IT, Kennett GA, Gadre A, Ham P, Hayward CJ, Martin RT, Thompson M, Wood MD, Baxter GS, Glen A, et al. Forbes IT, et al. J Med Chem. 1993 Apr 16;36(8):1104-7. doi: 10.1021/jm00060a019. J Med Chem. 1993. PMID: 8478907 No abstract available.

8

In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties.

Kennett GA, Wood MD, Bright F, Cilia J, Piper DC, Gager T, Thomas D, Baxter GS, Forbes IT, Ham P, Blackburn TP. Kennett GA, et al. Among authors: forbes it. Br J Pharmacol. 1996 Feb;117(3):427-434. doi: 10.1111/j.1476-5381.1996.tb15208.x. Br J Pharmacol. 1996. PMID: 8821530 Free PMC article.

9

Synthesis, biological activity, and molecular modeling of selective 5-HT(2C/2B) receptor antagonists.

Forbes IT, Dabbs S, Duckworth DM, Ham P, Jones GE, King FD, Saunders DV, Blaney FE, Naylor CB, Baxter GS, Blackburn TP, Kennett GA, Wood MD. Forbes IT, et al. J Med Chem. 1996 Dec 6;39(25):4966-77. doi: 10.1021/jm960571v. J Med Chem. 1996. PMID: 8960557

10

SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist.

Kennett GA, Wood MD, Bright F, Trail B, Riley G, Holland V, Avenell KY, Stean T, Upton N, Bromidge S, Forbes IT, Brown AM, Middlemiss DN, Blackburn TP. Kennett GA, et al. Among authors: forbes it. Neuropharmacology. 1997 Apr-May;36(4-5):609-20. doi: 10.1016/s0028-3908(97)00038-5. Neuropharmacology. 1997. PMID: 9225286

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