Degen JL - Search Results

1

Prothrombin deficiency results in embryonic and neonatal lethality in mice.

Sun WY, Witte DP, Degen JL, Colbert MC, Burkart MC, Holmbäck K, Xiao Q, Bugge TH, Degen SJ. Sun WY, et al. Among authors: degen sj, degen jl. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7597-602. doi: 10.1073/pnas.95.13.7597. Proc Natl Acad Sci U S A. 1998. PMID: 9636195 Free PMC article.

2

Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain.

Mullins ES, Kombrinck KW, Talmage KE, Shaw MA, Witte DP, Ullman JM, Degen SJ, Sun W, Flick MJ, Degen JL. Mullins ES, et al. Among authors: degen sj, degen jl. Blood. 2009 Jan 15;113(3):696-704. doi: 10.1182/blood-2008-07-169003. Epub 2008 Oct 16. Blood. 2009. PMID: 18927430 Free PMC article.

3

Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation.

Bugge TH, Xiao Q, Kombrinck KW, Flick MJ, Holmbäck K, Danton MJ, Colbert MC, Witte DP, Fujikawa K, Davie EW, Degen JL. Bugge TH, et al. Among authors: degen jl. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6258-63. doi: 10.1073/pnas.93.13.6258. Proc Natl Acad Sci U S A. 1996. PMID: 8692802 Free PMC article.

4

Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis.

Xiao Q, Danton MJ, Witte DP, Kowala MC, Valentine MT, Bugge TH, Degen JL. Xiao Q, et al. Among authors: degen jl. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10335-40. doi: 10.1073/pnas.94.19.10335. Proc Natl Acad Sci U S A. 1997. PMID: 9294211 Free PMC article.

5

Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver.

Bezerra JA, Bugge TH, Melin-Aldana H, Sabla G, Kombrinck KW, Witte DP, Degen JL. Bezerra JA, et al. Among authors: degen jl. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15143-8. doi: 10.1073/pnas.96.26.15143. Proc Natl Acad Sci U S A. 1999. PMID: 10611352 Free PMC article.

6

Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.

Bugge TH, Flick MJ, Daugherty CC, Degen JL. Bugge TH, et al. Among authors: degen jl. Genes Dev. 1995 Apr 1;9(7):794-807. doi: 10.1101/gad.9.7.794. Genes Dev. 1995. PMID: 7705657 Free article.

7

Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator.

Bugge TH, Flick MJ, Danton MJ, Daugherty CC, Romer J, Dano K, Carmeliet P, Collen D, Degen JL. Bugge TH, et al. Among authors: degen jl. Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5899-904. doi: 10.1073/pnas.93.12.5899. Proc Natl Acad Sci U S A. 1996. PMID: 8650190 Free PMC article.

8

Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3.

Holmbäck K, Danton MJ, Suh TT, Daugherty CC, Degen JL. Holmbäck K, et al. Among authors: degen jl. EMBO J. 1996 Nov 1;15(21):5760-71. EMBO J. 1996. PMID: 8918453 Free PMC article.

9

Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency.

Bugge TH, Kombrinck KW, Flick MJ, Daugherty CC, Danton MJ, Degen JL. Bugge TH, et al. Among authors: degen jl. Cell. 1996 Nov 15;87(4):709-19. doi: 10.1016/s0092-8674(00)81390-2. Cell. 1996. PMID: 8929539 Free article.

10

Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin.

Tsirka SE, Bugge TH, Degen JL, Strickland S. Tsirka SE, et al. Among authors: degen jl. Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9779-81. doi: 10.1073/pnas.94.18.9779. Proc Natl Acad Sci U S A. 1997. PMID: 9275201 Free PMC article.

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