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Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant.
Marchetti M, Rossi M, Giannelli V, Giuliani MM, Pizza M, Censini S, Covacci A, Massari P, Pagliaccia C, Manetti R, Telford JL, Douce G, Dougan G, Rappuoli R, Ghiara P. Marchetti M, et al. Among authors: giannelli v. Vaccine. 1998 Jan;16(1):33-7. doi: 10.1016/s0264-410x(97)00153-9. Vaccine. 1998. PMID: 9607006
Protease susceptibility and toxicity of heat-labile enterotoxins with a mutation in the active site or in the protease-sensitive loop.
Giannelli V, Fontana MR, Giuliani MM, Guangcai D, Rappuoli R, Pizza M. Giannelli V, et al. Infect Immun. 1997 Jan;65(1):331-4. doi: 10.1128/iai.65.1.331-334.1997. Infect Immun. 1997. PMID: 8975934 Free PMC article.
To generate nontoxic derivatives of Escherichia coli heat-labile enterotoxin (LT), site-directed mutagenesis has been used to change either the amino acid residues located in the catalytic site (M. Pizza, M. Domenighini, W. Hol, V. Giannelli, M. R. Fontana, M. M. Gi …
To generate nontoxic derivatives of Escherichia coli heat-labile enterotoxin (LT), site-directed mutagenesis has been used to change either …
85 results