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Pyrrolidine-3-carboxylic acids as endothelin antagonists. 3. Discovery of a potent, 2-nonaryl, highly selective ETA antagonist (A-216546).
J Med Chem. 1998 Aug 13;41(17):3261-75. doi: 10.1021/jm980217s.
J Med Chem. 1998.
PMID: 9703472
Design, synthesis, and activity of a series of pyrrolidine-3-carboxylic acid-based, highly specific, orally active ET(B) antagonists containing a diphenylmethylamine acetamide side chain.
Liu G, Kozmina NS, Winn M, von Geldern TW, Chiou WJ, Dixon DB, Nguyen B, Marsh KC, Opgenorth TJ.
Liu G, et al. Among authors: kozmina ns.
J Med Chem. 1999 Sep 9;42(18):3679-89. doi: 10.1021/jm990171i.
J Med Chem. 1999.
PMID: 10479299
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