Wasicak J - Search Results

1

Pyrrolidine-3-carboxylic acids as endothelin antagonists. 3. Discovery of a potent, 2-nonaryl, highly selective ETA antagonist (A-216546).

Liu G, Henry KJ Jr, Szczepankiewicz BG, Winn M, Kozmina NS, Boyd SA, Wasicak J, von Geldern TW, Wu-Wong JR, Chiou WJ, Dixon DB, Nguyen B, Marsh KC, Opgenorth TJ. Liu G, et al. Among authors: wasicak j. J Med Chem. 1998 Aug 13;41(17):3261-75. doi: 10.1021/jm980217s. J Med Chem. 1998. PMID: 9703472

2

Discovery of a series of cyclohexylethylamine-containing protein farnesyltransferase inhibitors exhibiting potent cellular activity.

Henry KJ Jr, Wasicak J, Tasker AS, Cohen J, Ewing P, Mitten M, Larsen JJ, Kalvin DM, Swenson R, Ng SC, Saeed B, Cherian S, Sham H, Rosenberg SH. Henry KJ Jr, et al. Among authors: wasicak j. J Med Chem. 1999 Nov 18;42(23):4844-52. doi: 10.1021/jm990335v. J Med Chem. 1999. PMID: 10579847

3

Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors.

Abreo MA, Lin NH, Garvey DS, Gunn DE, Hettinger AM, Wasicak JT, Pavlik PA, Martin YC, Donnelly-roberts DL, Anderson DJ, Sullivan JP, Williams M, Arneric SP, Holladay MW. Abreo MA, et al. Among authors: wasicak jt. J Med Chem. 1996 Feb 16;39(4):817-25. doi: 10.1021/jm9506884. J Med Chem. 1996. PMID: 8632405

4

Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors.

Holladay MW, Wasicak JT, Lin NH, He Y, Ryther KB, Bannon AW, Buckley MJ, Kim DJ, Decker MW, Anderson DJ, Campbell JE, Kuntzweiler TA, Donnelly-Roberts DL, Piattoni-Kaplan M, Briggs CA, Williams M, Arneric SP. Holladay MW, et al. Among authors: wasicak jt. J Med Chem. 1998 Feb 12;41(4):407-12. doi: 10.1021/jm9706224. J Med Chem. 1998. PMID: 9484491

5

Structure-activity studies on a novel series of cholinergic channel activators based on a heteroaryl ether framework.

Lin NH, Abreo MA, Gunn DE, Lebold SA, Lee EL, Wasicak JT, Hettinger AM, Daanen JF, Garvey DS, Campbell JE, Sullivan JP, Williams M, Arneric SP. Lin NH, et al. Among authors: wasicak jt. Bioorg Med Chem Lett. 1999 Sep 20;9(18):2747-52. doi: 10.1016/s0960-894x(99)00462-x. Bioorg Med Chem Lett. 1999. PMID: 10509928

6

Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice.

Holladay MW, Bai H, Li Y, Lin NH, Daanen JF, Ryther KB, Wasicak JT, Kincaid JF, He Y, Hettinger AM, Huang P, Anderson DJ, Bannon AW, Buckley MJ, Campbell JE, Donnelly-Roberts DL, Gunther KL, Kim DJ, Kuntzweiler TA, Sullivan JP, Decker MW, Arneric SP. Holladay MW, et al. Among authors: wasicak jt. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2797-802. doi: 10.1016/s0960-894x(98)00504-6. Bioorg Med Chem Lett. 1998. PMID: 9873625

7

Ligands for brain cholinergic channel receptors: synthesis and in vitro characterization of novel isoxazoles and isothiazoles as bioisosteric replacements for the pyridine ring in nicotine.

Garvey DS, Wasicak JT, Elliott RL, Lebold SA, Hettinger AM, Carrera GM, Lin NH, He Y, Holladay MW, Anderson DJ, et al. Garvey DS, et al. Among authors: wasicak jt. J Med Chem. 1994 Dec 23;37(26):4455-63. doi: 10.1021/jm00052a005. J Med Chem. 1994. PMID: 7799396

8

Synthesis and in vitro characterization of novel amino terminally modified oxotremorine derivatives for brain muscarinic receptors.

Garvey DS, Wasicak JT, Chung JY, Shue YK, Carrera GM, May PD, McKinney MM, Anderson D, Cadman E, Vella-Rountree L, et al. Garvey DS, et al. Among authors: wasicak jt. J Med Chem. 1992 May 1;35(9):1550-7. doi: 10.1021/jm00087a008. J Med Chem. 1992. PMID: 1578480

9

Novel isoxazoles which interact with brain cholinergic channel receptors have intrinsic cognitive enhancing and anxiolytic activities.

Garvey DS, Wasicak JT, Decker MW, Brioni JD, Buckley MJ, Sullivan JP, Carrera GM, Holladay MW, Arneric SP, Williams M. Garvey DS, et al. Among authors: wasicak jt. J Med Chem. 1994 Apr 15;37(8):1055-9. doi: 10.1021/jm00034a002. J Med Chem. 1994. PMID: 7909335 No abstract available.

10

Characterization of [3H]ABT-418: a novel cholinergic channel ligand.

Anderson DJ, Williams M, Pauly JR, Raszkiewicz JL, Campbell JE, Rotert G, Surber B, Thomas SB, Wasicak J, Arneric SP, et al. Anderson DJ, et al. Among authors: wasicak j. J Pharmacol Exp Ther. 1995 Jun;273(3):1434-41. J Pharmacol Exp Ther. 1995. PMID: 7791118

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