Kuo LC - Search Results

1

Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme.

Munshi S, Chen Z, Li Y, Olsen DB, Fraley ME, Hungate RW, Kuo LC. Munshi S, et al. Among authors: kuo lc. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):1053-60. doi: 10.1107/s0907444998003588. Acta Crystallogr D Biol Crystallogr. 1998. PMID: 9757136

2

Three-dimensional structure of a mutant HIV-1 protease displaying cross-resistance to all protease inhibitors in clinical trials.

Chen Z, Li Y, Schock HB, Hall D, Chen E, Kuo LC. Chen Z, et al. Among authors: kuo lc. J Biol Chem. 1995 Sep 15;270(37):21433-6. doi: 10.1074/jbc.270.37.21433. J Biol Chem. 1995. PMID: 7665551 Free article.

3

Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases.

Chen Z, Li Y, Chen E, Hall DL, Darke PL, Culberson C, Shafer JA, Kuo LC. Chen Z, et al. Among authors: kuo lc. J Biol Chem. 1994 Oct 21;269(42):26344-8. J Biol Chem. 1994. PMID: 7929352 Free article.

4

Non-active site changes elicit broad-based cross-resistance of the HIV-1 protease to inhibitors.

Olsen DB, Stahlhut MW, Rutkowski CA, Schock HB, vanOlden AL, Kuo LC. Olsen DB, et al. Among authors: kuo lc. J Biol Chem. 1999 Aug 20;274(34):23699-701. doi: 10.1074/jbc.274.34.23699. J Biol Chem. 1999. PMID: 10446127 Free article.

5

An alternate binding site for the P1-P3 group of a class of potent HIV-1 protease inhibitors as a result of concerted structural change in the 80s loop of the protease.

Munshi S, Chen Z, Yan Y, Li Y, Olsen DB, Schock HB, Galvin BB, Dorsey B, Kuo LC. Munshi S, et al. Among authors: kuo lc. Acta Crystallogr D Biol Crystallogr. 2000 Apr;56(Pt 4):381-8. doi: 10.1107/s0907444900000469. Acta Crystallogr D Biol Crystallogr. 2000. PMID: 10739910

6

Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases.

Coburn CA, Stachel SJ, Li YM, Rush DM, Steele TG, Chen-Dodson E, Holloway MK, Xu M, Huang Q, Lai MT, DiMuzio J, Crouthamel MC, Shi XP, Sardana V, Chen Z, Munshi S, Kuo L, Makara GM, Annis DA, Tadikonda PK, Nash HM, Vacca JP, Wang T. Coburn CA, et al. J Med Chem. 2004 Dec 2;47(25):6117-9. doi: 10.1021/jm049388p. J Med Chem. 2004. PMID: 15566281

7

Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors.

Huang S, Garbaccio RM, Fraley ME, Steen J, Kreatsoulas C, Hartman G, Stirdivant S, Drakas B, Rickert K, Walsh E, Hamilton K, Buser CA, Hardwick J, Mao X, Abrams M, Beck S, Tao W, Lobell R, Sepp-Lorenzino L, Yan Y, Ikuta M, Murphy JZ, Sardana V, Munshi S, Kuo L, Reilly M, Mahan E. Huang S, et al. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5907-12. doi: 10.1016/j.bmcl.2006.08.053. Epub 2006 Sep 20. Bioorg Med Chem Lett. 2006. PMID: 16990002

8

Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase.

Garbaccio RM, Huang S, Tasber ES, Fraley ME, Yan Y, Munshi S, Ikuta M, Kuo L, Kreatsoulas C, Stirdivant S, Drakas B, Rickert K, Walsh ES, Hamilton KA, Buser CA, Hardwick J, Mao X, Beck SC, Abrams MT, Tao W, Lobell R, Sepp-Lorenzino L, Hartman GD. Garbaccio RM, et al. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6280-5. doi: 10.1016/j.bmcl.2007.09.007. Epub 2007 Sep 7. Bioorg Med Chem Lett. 2007. PMID: 17900896

9

HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1' substituent.

Duffy JL, Kirk BA, Kevin NJ, Chapman KT, Schleif WA, Olsen DB, Stahlhut M, Rutkowski CA, Kuo LC, Jin L, Lin JH, Emini EA, Tata JR. Duffy JL, et al. Among authors: kuo lc. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3323-6. doi: 10.1016/s0960-894x(03)00680-2. Bioorg Med Chem Lett. 2003. PMID: 12951118

10

Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 A resolution.

Munshi S, Hall DL, Kornienko M, Darke PL, Kuo LC. Munshi S, et al. Among authors: kuo lc. Acta Crystallogr D Biol Crystallogr. 2003 Oct;59(Pt 10):1725-30. doi: 10.1107/s0907444903015415. Epub 2003 Sep 19. Acta Crystallogr D Biol Crystallogr. 2003. PMID: 14501110

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