Jenkins TC - Search Results

1

Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones.

Perry PJ, Reszka AP, Wood AA, Read MA, Gowan SM, Dosanjh HS, Trent JO, Jenkins TC, Kelland LR, Neidle S. Perry PJ, et al. Among authors: jenkins tc. J Med Chem. 1998 Nov 19;41(24):4873-84. doi: 10.1021/jm981067o. J Med Chem. 1998. PMID: 9822556

2

Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives.

Agbandje M, Jenkins TC, McKenna R, Reszka AP, Neidle S. Agbandje M, et al. Among authors: jenkins tc. J Med Chem. 1992 Apr 17;35(8):1418-29. doi: 10.1021/jm00086a010. J Med Chem. 1992. PMID: 1573635

3

Structure of a covalent DNA minor groove adduct with a pyrrolobenzodiazepine dimer: evidence for sequence-specific interstrand cross-linking.

Jenkins TC, Hurley LH, Neidle S, Thurston DE. Jenkins TC, et al. J Med Chem. 1994 Dec 23;37(26):4529-37. doi: 10.1021/jm00052a012. J Med Chem. 1994. PMID: 7799403

4

1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase.

Perry PJ, Gowan SM, Reszka AP, Polucci P, Jenkins TC, Kelland LR, Neidle S. Perry PJ, et al. Among authors: jenkins tc. J Med Chem. 1998 Aug 13;41(17):3253-60. doi: 10.1021/jm9801105. J Med Chem. 1998. PMID: 9703471

5

Anthracene-9,10-diones as potential anticancer agents: bacterial mutation studies of amido-substituted derivatives reveal an unexpected lack of mutagenicity.

Venitt S, Crofton-Sleigh C, Agbandje M, Jenkins TC, Neidle S. Venitt S, et al. Among authors: jenkins tc. J Med Chem. 1998 Sep 10;41(19):3748-52. doi: 10.1021/jm980167r. J Med Chem. 1998. PMID: 9733500

6

DNA tetraplex-binding drugs: structure-selective targeting is critical for antitumour telomerase inhibition.

Perry PJ, Jenkins TC. Perry PJ, et al. Among authors: jenkins tc. Mini Rev Med Chem. 2001 May;1(1):31-41. doi: 10.2174/1389557013407304. Mini Rev Med Chem. 2001. PMID: 12369989 Review.

7

Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents.

Antonow D, Kaliszczak M, Kang GD, Coffils M, Tiberghien AC, Cooper N, Barata T, Heidelberger S, James CH, Zloh M, Jenkins TC, Reszka AP, Neidle S, Guichard SM, Jodrell DI, Hartley JA, Howard PW, Thurston DE. Antonow D, et al. Among authors: jenkins tc. J Med Chem. 2010 Apr 8;53(7):2927-41. doi: 10.1021/jm901722v. J Med Chem. 2010. PMID: 20218628

8

Molecular modelling of DNA-antitumour drug intercalation interactions: correlation of structural and energetic features with biological properties for a series of phenylquinoline-8-carboxamide compounds.

McKenna R, Beveridge AJ, Jenkins TC, Neidle S, Denny WA. McKenna R, et al. Among authors: jenkins tc. Mol Pharmacol. 1989 May;35(5):720-8. Mol Pharmacol. 1989. PMID: 2725476

9

Detection and kinetic studies of triplex formation by oligodeoxynucleotides using real-time biomolecular interaction analysis (BIA).

Bates PJ, Dosanjh HS, Kumar S, Jenkins TC, Laughton CA, Neidle S. Bates PJ, et al. Among authors: jenkins tc. Nucleic Acids Res. 1995 Sep 25;23(18):3627-32. doi: 10.1093/nar/23.18.3627. Nucleic Acids Res. 1995. PMID: 7478988 Free PMC article.

10

A molecular anchor for stabilizing triple-helical DNA.

Fox KR, Polucci P, Jenkins TC, Neidle S. Fox KR, et al. Among authors: jenkins tc. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7887-91. doi: 10.1073/pnas.92.17.7887. Proc Natl Acad Sci U S A. 1995. PMID: 7644509 Free PMC article.

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