Kelland LR - Search Results

1

Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones.

Perry PJ, Reszka AP, Wood AA, Read MA, Gowan SM, Dosanjh HS, Trent JO, Jenkins TC, Kelland LR, Neidle S. Perry PJ, et al. Among authors: kelland lr. J Med Chem. 1998 Nov 19;41(24):4873-84. doi: 10.1021/jm981067o. J Med Chem. 1998. PMID: 9822556

2

1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase.

Perry PJ, Gowan SM, Reszka AP, Polucci P, Jenkins TC, Kelland LR, Neidle S. Perry PJ, et al. Among authors: kelland lr. J Med Chem. 1998 Aug 13;41(17):3253-60. doi: 10.1021/jm9801105. J Med Chem. 1998. PMID: 9703471

3

2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase.

Perry PJ, Read MA, Davies RT, Gowan SM, Reszka AP, Wood AA, Kelland LR, Neidle S. Perry PJ, et al. Among authors: kelland lr. J Med Chem. 1999 Jul 15;42(14):2679-84. doi: 10.1021/jm990084q. J Med Chem. 1999. PMID: 10411488

4

Human telomerase inhibition by substituted acridine derivatives.

Harrison RJ, Gowan SM, Kelland LR, Neidle S. Harrison RJ, et al. Among authors: kelland lr. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2463-8. doi: 10.1016/s0960-894x(99)00394-7. Bioorg Med Chem Lett. 1999. PMID: 10498189

5

Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure-activity relationships.

Read MA, Wood AA, Harrison JR, Gowan SM, Kelland LR, Dosanjh HS, Neidle S. Read MA, et al. Among authors: kelland lr. J Med Chem. 1999 Nov 4;42(22):4538-46. doi: 10.1021/jm990287e. J Med Chem. 1999. PMID: 10579817

6

Telomerase as an anti-cancer target: current status and future prospects.

Neidle S, Kelland LR. Neidle S, et al. Among authors: kelland lr. Anticancer Drug Des. 1999 Aug;14(4):341-7. Anticancer Drug Des. 1999. PMID: 10625926 Review.

7

Design, synthesis and evaluation of human telomerase inhibitors based upon a tetracyclic structural motif.

Perry PJ, Gowan SM, Read MA, Kelland LR, Neidle S. Perry PJ, et al. Among authors: kelland lr. Anticancer Drug Des. 1999 Aug;14(4):373-82. Anticancer Drug Des. 1999. PMID: 10625930

8

Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors.

Read M, Harrison RJ, Romagnoli B, Tanious FA, Gowan SH, Reszka AP, Wilson WD, Kelland LR, Neidle S. Read M, et al. Among authors: kelland lr. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):4844-9. doi: 10.1073/pnas.081560598. Epub 2001 Apr 17. Proc Natl Acad Sci U S A. 2001. PMID: 11309493 Free PMC article.

9

Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes.

Gowan SM, Heald R, Stevens MF, Kelland LR. Gowan SM, et al. Among authors: kelland lr. Mol Pharmacol. 2001 Nov;60(5):981-8. doi: 10.1124/mol.60.5.981. Mol Pharmacol. 2001. PMID: 11641426

10

A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity.

Gowan SM, Harrison JR, Patterson L, Valenti M, Read MA, Neidle S, Kelland LR. Gowan SM, et al. Among authors: kelland lr. Mol Pharmacol. 2002 May;61(5):1154-62. doi: 10.1124/mol.61.5.1154. Mol Pharmacol. 2002. PMID: 11961134

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