Neidle S - Search Results

1

Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones.

Perry PJ, Reszka AP, Wood AA, Read MA, Gowan SM, Dosanjh HS, Trent JO, Jenkins TC, Kelland LR, Neidle S. Perry PJ, et al. Among authors: neidle s. J Med Chem. 1998 Nov 19;41(24):4873-84. doi: 10.1021/jm981067o. J Med Chem. 1998. PMID: 9822556

2

A molecular modeling study of the interactions between the antiestrogen drug tamoxifen and several derivatives, and the calcium-binding protein calmodulin.

Edwards KJ, Laughton CA, Neidle S. Edwards KJ, et al. Among authors: neidle s. J Med Chem. 1992 Jul 24;35(15):2753-61. doi: 10.1021/jm00093a006. J Med Chem. 1992. PMID: 1322985

3

Substituent position dictates the intercalative DNA-binding mode for anthracene-9,10-dione antitumor drugs.

Tanious FA, Jenkins TC, Neidle S, Wilson WD. Tanious FA, et al. Among authors: neidle s. Biochemistry. 1992 Nov 24;31(46):11632-40. doi: 10.1021/bi00161a050. Biochemistry. 1992. PMID: 1445899

Molecular modeling studies [Islam, S.A., Neidle, S., Gandecha, B.M., Partridge, M., Patterson, L.H., & Brown, J.R. (1985) J. ...Modeling studies also suggested that anthracene-9,10-dione (anthraquinone) derivatives substituted at the 2,6 positions with -N …

Molecular modeling studies [Islam, S.A., Neidle, S., Gandecha, B.M., Partridge, M., Patterson, L.H., & Brown, J.R. …

4

Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives.

Agbandje M, Jenkins TC, McKenna R, Reszka AP, Neidle S. Agbandje M, et al. Among authors: neidle s. J Med Chem. 1992 Apr 17;35(8):1418-29. doi: 10.1021/jm00086a010. J Med Chem. 1992. PMID: 1573635

5

Crystal structure of a pentamidine-oligonucleotide complex: implications for DNA-binding properties.

Edwards KJ, Jenkins TC, Neidle S. Edwards KJ, et al. Among authors: neidle s. Biochemistry. 1992 Aug 11;31(31):7104-9. doi: 10.1021/bi00146a011. Biochemistry. 1992. PMID: 1643044

6

Molecular modeling to study DNA intercalation by anti-tumor drugs.

Neidle S, Jenkins TC. Neidle S, et al. Methods Enzymol. 1991;203:433-58. doi: 10.1016/0076-6879(91)03024-b. Methods Enzymol. 1991. PMID: 1762566 No abstract available.

7

Studies on 1,3-diaryltriazene analogues of berenil: molecules with potential GC base-pair selectivity.

Walton AR, Jenkins TC, Neidle S. Walton AR, et al. Among authors: neidle s. Acta Crystallogr B. 1991 Oct 1;47 ( Pt 5):771-5. doi: 10.1107/s0108768191004524. Acta Crystallogr B. 1991. PMID: 1793543

8

Interaction of berenil with the EcoRI dodecamer d(CGCGAATTCGCG)2 in solution studied by NMR.

Lane AN, Jenkins TC, Brown T, Neidle S. Lane AN, et al. Among authors: neidle s. Biochemistry. 1991 Feb 5;30(5):1372-85. doi: 10.1021/bi00219a030. Biochemistry. 1991. PMID: 1991117

9

Interaction of berenil with the tyrT DNA sequence studied by footprinting and molecular modelling. Implications for the design of sequence-specific DNA recognition agents.

Laughton CA, Jenkins TC, Fox KR, Neidle S. Laughton CA, et al. Among authors: neidle s. Nucleic Acids Res. 1990 Aug 11;18(15):4479-88. doi: 10.1093/nar/18.15.4479. Nucleic Acids Res. 1990. PMID: 2167469 Free PMC article.

10

Inhibitors of the P450 enzymes aromatase and lyase. Crystallographic and molecular modeling studies suggest structural features of pyridylacetic acid derivatives responsible for differences in enzyme inhibitory activity.

Laughton CA, Neidle S. Laughton CA, et al. Among authors: neidle s. J Med Chem. 1990 Nov;33(11):3055-60. doi: 10.1021/jm00173a023. J Med Chem. 1990. PMID: 2231605

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