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Orally active indole N-oxide PDE4 inhibitors.
Hulme C, Mathew R, Moriarty K, Miller B, Ramanjulu M, Cox P, Souness J, Page KM, Uhl J, Travis J, Labaudiniere R, Huang F, Djuric SW. Hulme C, et al. Among authors: mathew r. Bioorg Med Chem Lett. 1998 Nov 3;8(21):3053-8. doi: 10.1016/s0960-894x(98)00572-1. Bioorg Med Chem Lett. 1998. PMID: 9873675
Nanomolar Inhibitors for Two Distinct Biological Target Families from a Single Synthetic Sequence: A Next Step in Combinatorial Library Design?
Burns CJ, Groneberg RD, Salvino JM, McGeehan G, Condon SM, Morris R, Morrissette M, Mathew R, Darnbrough S, Neuenschwander K, Scotese A, Djuric SW, Ullrich J, Labaudiniere R. Burns CJ, et al. Among authors: mathew r. Angew Chem Int Ed Engl. 1998 Nov 2;37(20):2848-2850. doi: 10.1002/(SICI)1521-3773(19981102)37:20<2848::AID-ANIE2848>3.0.CO;2-C. Angew Chem Int Ed Engl. 1998. PMID: 29711099
Solid-phase synthesis of an arylsulfone hydroxamate library.
Salvino JM, Mathew R, Kiesow T, Narensingh R, Mason HJ, Dodd A, Groneberg R, Burns CJ, McGeehan G, Kline J, Orton E, Tang SY, Morrisette M, Labaudininiere R. Salvino JM, et al. Among authors: mathew r. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1637-40. doi: 10.1016/s0960-894x(00)00285-7. Bioorg Med Chem Lett. 2000. PMID: 10937713
Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of betaII tryptase.
Levell J, Astles P, Eastwood P, Cairns J, Houille O, Aldous S, Merriman G, Whiteley B, Pribish J, Czekaj M, Liang G, Maignan S, Guilloteau JP, Dupuy A, Davidson J, Harrison T, Morley A, Watson S, Fenton G, McCarthy C, Romano J, Mathew R, Engers D, Gardyan M, Sides K, Kwong J, Tsay J, Rebello S, Shen L, Wang J, Luo Y, Giardino O, Lim HK, Smith K, Pauls H. Levell J, et al. Among authors: mathew r. Bioorg Med Chem. 2005 Apr 15;13(8):2859-72. doi: 10.1016/j.bmc.2005.02.014. Bioorg Med Chem. 2005. PMID: 15781396
1,251 results