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Page 1
Orally active indole N-oxide PDE4 inhibitors.
Hulme C, Mathew R, Moriarty K, Miller B, Ramanjulu M, Cox P, Souness J, Page KM, Uhl J, Travis J, Labaudiniere R, Huang F, Djuric SW. Hulme C, et al. Among authors: moriarty k. Bioorg Med Chem Lett. 1998 Nov 3;8(21):3053-8. doi: 10.1016/s0960-894x(98)00572-1. Bioorg Med Chem Lett. 1998. PMID: 9873675
Benzofuran based PDE4 inhibitors.
McGarry DG, Regan JR, Volz FA, Hulme C, Moriarty KJ, Djuric SW, Souness JE, Miller BE, Travis JJ, Sweeney DM. McGarry DG, et al. Among authors: moriarty kj. Bioorg Med Chem. 1999 Jun;7(6):1131-9. doi: 10.1016/s0968-0896(99)00038-3. Bioorg Med Chem. 1999. PMID: 10428384
Novel cytokine release inhibitors. Part I: Triterpenes.
Huang FC, Chan WK, Moriarty KJ, Zhang DC, Chang MN, He W, Yu KT, Zilberstein A. Huang FC, et al. Among authors: moriarty kj. Bioorg Med Chem Lett. 1998 Jul 21;8(14):1883-6. doi: 10.1016/s0960-894x(98)00331-x. Bioorg Med Chem Lett. 1998. PMID: 9873452
5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk).
Winters MP, Robinson DJ, Khine HH, Pullen SS, Woska JR Jr, Raymond EL, Sellati R, Cywin CL, Snow RJ, Kashem MA, Wolak JP, King J, Kaplita PV, Liu LH, Farrell TM, DesJarlais R, Roth GP, Takahashi H, Moriarty KJ. Winters MP, et al. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5541-4. doi: 10.1016/j.bmcl.2008.09.016. Epub 2008 Sep 7. Bioorg Med Chem Lett. 2008. PMID: 18823779
The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase.
Leftheris K, Ahmed G, Chan R, Dyckman AJ, Hussain Z, Ho K, Hynes J Jr, Letourneau J, Li W, Lin S, Metzger A, Moriarty KJ, Riviello C, Shimshock Y, Wen J, Wityak J, Wrobleski ST, Wu H, Wu J, Desai M, Gillooly KM, Lin TH, Loo D, McIntyre KW, Pitt S, Shen DR, Shuster DJ, Zhang R, Diller D, Doweyko A, Sack J, Baldwin J, Barrish J, Dodd J, Henderson I, Kanner S, Schieven GL, Webb M. Leftheris K, et al. Among authors: moriarty kj. J Med Chem. 2004 Dec 2;47(25):6283-91. doi: 10.1021/jm049521d. J Med Chem. 2004. PMID: 15566298
284 results