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Addition of a missense mutation present in the L gene of respiratory syncytial virus (RSV) cpts530/1030 to RSV vaccine candidate cpts248/404 increases its attenuation and temperature sensitivity.
Whitehead SS, Firestone CY, Karron RA, Crowe JE Jr, Elkins WR, Collins PL, Murphy BR. Whitehead SS, et al. Among authors: karron ra. J Virol. 1999 Feb;73(2):871-7. doi: 10.1128/JVI.73.2.871-877.1999. J Virol. 1999. PMID: 9882287 Free PMC article. Clinical Trial.
Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant.
Karron RA, Buonagurio DA, Georgiu AF, Whitehead SS, Adamus JE, Clements-Mann ML, Harris DO, Randolph VB, Udem SA, Murphy BR, Sidhu MS. Karron RA, et al. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13961-6. doi: 10.1073/pnas.94.25.13961. Proc Natl Acad Sci U S A. 1997. PMID: 9391135 Free PMC article.
190 results