Appella E - Search Results

1

Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers.

Turpin JA, Song Y, Inman JK, Huang M, Wallqvist A, Maynard A, Covell DG, Rice WG, Appella E. Turpin JA, et al. Among authors: appella e. J Med Chem. 1999 Jan 14;42(1):67-86. doi: 10.1021/jm9802517. J Med Chem. 1999. PMID: 9888834

2

Studies on the mechanism of inactivation of the HIV-1 nucleocapsid protein NCp7 with 2-mercaptobenzamide thioesters.

Jenkins LM, Byrd JC, Hara T, Srivastava P, Mazur SJ, Stahl SJ, Inman JK, Appella E, Omichinski JG, Legault P. Jenkins LM, et al. Among authors: appella e. J Med Chem. 2005 Apr 21;48(8):2847-58. doi: 10.1021/jm0492195. J Med Chem. 2005. PMID: 15828823

3

Benzamide-based thiolcarbamates: a new class of HIV-1 NCp7 inhibitors.

Goel A, Mazur SJ, Fattah RJ, Hartman TL, Turpin JA, Huang M, Rice WG, Appella E, Inman JK. Goel A, et al. Among authors: appella e. Bioorg Med Chem Lett. 2002 Mar 11;12(5):767-70. doi: 10.1016/s0960-894x(02)00007-0. Bioorg Med Chem Lett. 2002. PMID: 11858998

4

Synthesis and biological properties of amino acid amide ligand-based pyridinioalkanoyl thioesters as anti-HIV agents.

Song Y, Goel A, Basrur V, Roberts PE, Mikovits JA, Inman JK, Turpin JA, Rice WG, Appella E. Song Y, et al. Among authors: appella e. Bioorg Med Chem. 2002 May;10(5):1263-73. doi: 10.1016/s0968-0896(01)00392-3. Bioorg Med Chem. 2002. PMID: 11886789

5

Optimization of unique, uncharged thioesters as inhibitors of HIV replication.

Srivastava P, Schito M, Fattah RJ, Hara T, Hartman T, Buckheit RW Jr, Turpin JA, Inman JK, Appella E. Srivastava P, et al. Among authors: appella e. Bioorg Med Chem. 2004 Dec 15;12(24):6437-50. doi: 10.1016/j.bmc.2004.09.032. Bioorg Med Chem. 2004. PMID: 15556761

6

Inactivation of HIV-1 nucleocapsid protein P7 by pyridinioalkanoyl thioesters. Characterization of reaction products and proposed mechanism of action.

Basrur V, Song Y, Mazur SJ, Higashimoto Y, Turpin JA, Rice WG, Inman JK, Appella E. Basrur V, et al. Among authors: appella e. J Biol Chem. 2000 May 19;275(20):14890-7. doi: 10.1074/jbc.275.20.14890. J Biol Chem. 2000. PMID: 10809733 Free article.

K., Huang, M., Wallqvist, A., Maynard, A., Covell, D. G., Rice, W. G., and Appella, E. (1999) J. Med. Chem. 42, 67-86). In the present study, fluorescence and electrospray ionization-mass spectrometry were employed to determine the mechanism of modification of NCp7 …

K., Huang, M., Wallqvist, A., Maynard, A., Covell, D. G., Rice, W. G., and Appella, E. (1999) J. Med. Chem. 42, 67-86). In the …

7

Preclinical evaluation of a zinc finger inhibitor targeting lentivirus nucleocapsid protein in SIV-infected monkeys.

Schito ML, Soloff AC, Slovitz D, Trichel A, Inman JK, Appella E, Turpin JA, Barratt-Boyes SM. Schito ML, et al. Among authors: appella e. Curr HIV Res. 2006 Jul;4(3):379-86. doi: 10.2174/157016206777709492. Curr HIV Res. 2006. PMID: 16842089

8

In vivo antiviral activity of novel human immunodeficiency virus type 1 nucleocapsid p7 zinc finger inhibitors in a transgenic murine model.

Schito ML, Goel A, Song Y, Inman JK, Fattah RJ, Rice WG, Turpin JA, Sher A, Appella E. Schito ML, et al. Among authors: appella e. AIDS Res Hum Retroviruses. 2003 Feb;19(2):91-101. doi: 10.1089/088922203762688595. AIDS Res Hum Retroviruses. 2003. PMID: 12639244

9

Comparison of the specificity of interaction of cellular and viral zinc-binding domains with 2-mercaptobenzamide thioesters.

Jenkins LM, Durell SR, Maynard AT, Stahl SJ, Inman JK, Appella E, Legault P, Omichinski JG. Jenkins LM, et al. Among authors: appella e. J Am Chem Soc. 2006 Sep 13;128(36):11964-76. doi: 10.1021/ja063329e. J Am Chem Soc. 2006. PMID: 16953638

10

Topical microbicides: a promising approach for controlling the AIDS pandemic via retroviral zinc finger inhibitors.

Turpin JA, Schito ML, Jenkins LM, Inman JK, Appella E. Turpin JA, et al. Among authors: appella e. Adv Pharmacol. 2008;56:229-56. doi: 10.1016/S1054-3589(07)56008-4. Adv Pharmacol. 2008. PMID: 18086414 Review. No abstract available.

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