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Pharmacological inhibition of FTO.
McMurray F, Demetriades M, Aik W, Merkestein M, Kramer H, Andrew DS, Scudamore CL, Hough TA, Wells S, Ashcroft FM, McDonough MA, Schofield CJ, Cox RD. McMurray F, et al. PLoS One. 2015 Apr 1;10(4):e0121829. doi: 10.1371/journal.pone.0121829. eCollection 2015. PLoS One. 2015. PMID: 25830347 Free PMC article.
FTO influences adipogenesis by regulating mitotic clonal expansion.
Merkestein M, Laber S, McMurray F, Andrew D, Sachse G, Sanderson J, Li M, Usher S, Sellayah D, Ashcroft FM, Cox RD. Merkestein M, et al. Nat Commun. 2015 Apr 17;6:6792. doi: 10.1038/ncomms7792. Nat Commun. 2015. PMID: 25881961 Free PMC article.
Role for the obesity-related FTO gene in the cellular sensing of amino acids.
Gulati P, Cheung MK, Antrobus R, Church CD, Harding HP, Tung YC, Rimmington D, Ma M, Ron D, Lehner PJ, Ashcroft FM, Cox RD, Coll AP, O'Rahilly S, Yeo GS. Gulati P, et al. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2557-62. doi: 10.1073/pnas.1222796110. Epub 2013 Jan 28. Proc Natl Acad Sci U S A. 2013. PMID: 23359686 Free PMC article.