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14 results

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Page 1
The Beclin 1 network regulates autophagy and apoptosis.
Kang R, Zeh HJ, Lotze MT, Tang D. Kang R, et al. Cell Death Differ. 2011 Apr;18(4):571-80. doi: 10.1038/cdd.2010.191. Epub 2011 Feb 11. Cell Death Differ. 2011. PMID: 21311563 Free PMC article. Review.
In contrast, the BH3 domain of Beclin 1 is bound to, and inhibited by Bcl-2 or Bcl-XL. This interaction can be disrupted by phosphorylation of Bcl-2 and Beclin 1, or ubiquitination of Beclin 1. Interestingly, caspase-mediated cleavage of Beclin 1 promo …
In contrast, the BH3 domain of Beclin 1 is bound to, and inhibited by Bcl-2 or Bcl-XL. This interaction can be disrupted by phosphory …
Endogenous HMGB1 regulates autophagy.
Tang D, Kang R, Livesey KM, Cheh CW, Farkas A, Loughran P, Hoppe G, Bianchi ME, Tracey KJ, Zeh HJ 3rd, Lotze MT. Tang D, et al. J Cell Biol. 2010 Sep 6;190(5):881-92. doi: 10.1083/jcb.200911078. J Cell Biol. 2010. PMID: 20819940 Free PMC article.
Here we show that high mobility group box 1 (HMGB1), a chromatin-associated nuclear protein and extracellular damage-associated molecular pattern molecule, is a critical regulator of autophagy. ...
Here we show that high mobility group box 1 (HMGB1), a chromatin-associated nuclear protein and extracellular damage-associated molec …
p53/HMGB1 complexes regulate autophagy and apoptosis.
Livesey KM, Kang R, Vernon P, Buchser W, Loughran P, Watkins SC, Zhang L, Manfredi JJ, Zeh HJ 3rd, Li L, Lotze MT, Tang D. Livesey KM, et al. Cancer Res. 2012 Apr 15;72(8):1996-2005. doi: 10.1158/0008-5472.CAN-11-2291. Epub 2012 Feb 16. Cancer Res. 2012. PMID: 22345153 Free PMC article.
Here, we show that high mobility group box 1 (HMGB1) and p53 form a complex that regulates the balance between tumor cell death and survival. ...Conversely, knockout of HMGB1 in mouse embryonic fibroblasts increases p53 cytosolic localization and decreases autophagy. p53 i …
Here, we show that high mobility group box 1 (HMGB1) and p53 form a complex that regulates the balance between tumor cell death and s …
Autophagy inhibition in combination cancer treatment.
Livesey KM, Tang D, Zeh HJ, Lotze MT. Livesey KM, et al. Curr Opin Investig Drugs. 2009 Dec;10(12):1269-79. Curr Opin Investig Drugs. 2009. PMID: 19943199 Review.
Other strategies for the reversal of autophagy are based on the recent observation that the cytosolic location of the chromatin-binding protein HMGB1 (high-mobility group box-1) is associated with sustained autophagy. Targeting HMGB1 using platinum-containing compounds, et …
Other strategies for the reversal of autophagy are based on the recent observation that the cytosolic location of the chromatin-binding prot …
Progress in tuberculosis vaccine development and host-directed therapies--a state of the art review.
Kaufmann SH, Lange C, Rao M, Balaji KN, Lotze M, Schito M, Zumla AI, Maeurer M. Kaufmann SH, et al. Lancet Respir Med. 2014 Apr;2(4):301-20. doi: 10.1016/S2213-2600(14)70033-5. Epub 2014 Mar 24. Lancet Respir Med. 2014. PMID: 24717627 Review.
Tuberculosis continues to kill 1.4 million people annually. During the past 5 years, an alarming increase in the number of patients with multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis has been noted, particularly in eastern Europe, Asia, and s …
Tuberculosis continues to kill 1.4 million people annually. During the past 5 years, an alarming increase in the number of patients w …
Pharmacologic administration of interleukin-2.
Chavez AR, Buchser W, Basse PH, Liang X, Appleman LJ, Maranchie JK, Zeh H, de Vera ME, Lotze MT. Chavez AR, et al. Ann N Y Acad Sci. 2009 Dec;1182:14-27. doi: 10.1111/j.1749-6632.2009.05160.x. Ann N Y Acad Sci. 2009. PMID: 20074271
Cancer and inflammation: promise for biologic therapy.
Demaria S, Pikarsky E, Karin M, Coussens LM, Chen YC, El-Omar EM, Trinchieri G, Dubinett SM, Mao JT, Szabo E, Krieg A, Weiner GJ, Fox BA, Coukos G, Wang E, Abraham RT, Carbone M, Lotze MT. Demaria S, et al. J Immunother. 2010 May;33(4):335-51. doi: 10.1097/CJI.0b013e3181d32e74. J Immunother. 2010. PMID: 20386472 Free PMC article. Review.
HMGB1 release and redox regulates autophagy and apoptosis in cancer cells.
Tang D, Kang R, Cheh CW, Livesey KM, Liang X, Schapiro NE, Benschop R, Sparvero LJ, Amoscato AA, Tracey KJ, Zeh HJ, Lotze MT. Tang D, et al. Oncogene. 2010 Sep 23;29(38):5299-310. doi: 10.1038/onc.2010.261. Epub 2010 Jul 12. Oncogene. 2010. PMID: 20622903 Free PMC article.
In this study we show that the high-mobility group box 1 protein (HMGB1) is a redox-sensitive regulator of the balance between autophagy and apoptosis. ...
In this study we show that the high-mobility group box 1 protein (HMGB1) is a redox-sensitive regulator of the balance between autoph …
High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress.
Tang D, Kang R, Livesey KM, Zeh HJ 3rd, Lotze MT. Tang D, et al. Antioxid Redox Signal. 2011 Oct 15;15(8):2185-95. doi: 10.1089/ars.2010.3666. Epub 2011 Jun 6. Antioxid Redox Signal. 2011. PMID: 21395369 Free PMC article.
AIMS: Autophagy, the process by which cells break down spent biochemical and damaged components, plays an important role in cell survival following stress. High mobility group box 1 (HMGB1) regulates autophagy in response to oxidative stress. RESULTS: Exogenous hydrogen pe …
AIMS: Autophagy, the process by which cells break down spent biochemical and damaged components, plays an important role in cell survival fo …
14 results