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Fueling the Cell Division Cycle.
Salazar-Roa M, Malumbres M. Salazar-Roa M, et al. Trends Cell Biol. 2017 Jan;27(1):69-81. doi: 10.1016/j.tcb.2016.08.009. Epub 2016 Oct 13. Trends Cell Biol. 2017. PMID: 27746095 Review.
Plk1 overexpression induces chromosomal instability and suppresses tumor development.
de Cárcer G, Venkateswaran SV, Salgueiro L, El Bakkali A, Somogyi K, Rowald K, Montañés P, Sanclemente M, Escobar B, de Martino A, McGranahan N, Malumbres M, Sotillo R. de Cárcer G, et al. Nat Commun. 2018 Aug 1;9(1):3012. doi: 10.1038/s41467-018-05429-5. Nat Commun. 2018. PMID: 30069007 Free PMC article.
Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer.
Álvarez-Fernández M, Sanz-Flores M, Sanz-Castillo B, Salazar-Roa M, Partida D, Zapatero-Solana E, Ali HR, Manchado E, Lowe S, VanArsdale T, Shields D, Caldas C, Quintela-Fandino M, Malumbres M. Álvarez-Fernández M, et al. Cell Death Differ. 2018 May;25(5):828-840. doi: 10.1038/s41418-017-0024-0. Epub 2017 Dec 11. Cell Death Differ. 2018. PMID: 29229993 Free PMC article.
Thrombocytopenia-associated mutations in Ser/Thr kinase MASTL deregulate actin cytoskeletal dynamics in platelets.
Hurtado B, Trakala M, Ximénez-Embún P, El Bakkali A, Partida D, Sanz-Castillo B, Álvarez-Fernández M, Maroto M, Sánchez-Martínez R, Martínez L, Muñoz J, García de Frutos P, Malumbres M. Hurtado B, et al. J Clin Invest. 2018 Dec 3;128(12):5351-5367. doi: 10.1172/JCI121876. Epub 2018 Oct 29. J Clin Invest. 2018. PMID: 30252678 Free PMC article.
Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis.
de Cárcer G, Wachowicz P, Martínez-Martínez S, Oller J, Méndez-Barbero N, Escobar B, González-Loyola A, Takaki T, El Bakkali A, Cámara JA, Jiménez-Borreguero LJ, Bustelo XR, Cañamero M, Mulero F, de Los Ángeles Sevilla M, Montero MJ, Redondo JM, Malumbres M. de Cárcer G, et al. Nat Med. 2017 Aug;23(8):964-974. doi: 10.1038/nm.4364. Epub 2017 Jul 10. Nat Med. 2017. PMID: 28692064