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Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice.
Muzumdar RH, Huffman DM, Calvert JW, Jha S, Weinberg Y, Cui L, Nemkal A, Atzmon G, Klein L, Gundewar S, Ji SY, Lavu M, Predmore BL, Lefer DJ. Muzumdar RH, et al. Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):1940-8. doi: 10.1161/ATVBAHA.110.205997. Epub 2010 Jul 22. Arterioscler Thromb Vasc Biol. 2010. PMID: 20651283 Free PMC article.
The extent of myocardial infarction per area-at-risk was evaluated at 24 hours using Evans Blue dye and 2-3-5-triphenyl tetrazolium chloride staining. Left ventricular function was evaluated at 1 week after ischemia using high-resolution, 2D echocardiography (VisualSonics …
The extent of myocardial infarction per area-at-risk was evaluated at 24 hours using Evans Blue dye and 2-3-5-triphenyl tetrazolium c …
Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling.
Calvert JW, Gundewar S, Jha S, Greer JJ, Bestermann WH, Tian R, Lefer DJ. Calvert JW, et al. Diabetes. 2008 Mar;57(3):696-705. doi: 10.2337/db07-1098. Epub 2007 Dec 14. Diabetes. 2008. PMID: 18083782
OBJECTIVE: Clinical studies have reported that metformin reduces cardiovascular end points of type 2 diabetic subjects by actions that cannot solely be attributed to glucose-lowering effects. ...
OBJECTIVE: Clinical studies have reported that metformin reduces cardiovascular end points of type 2 diabetic subjects by actions tha …