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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA. Mills EL, et al. Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28. Nature. 2018. PMID: 29590092 Free PMC article.
NLRP3, the inflammasome and COVID-19 infection.
Yin M, Marrone L, Peace CG, O'Neill LAJ. Yin M, et al. QJM. 2023 Jul 28;116(7):502-507. doi: 10.1093/qjmed/hcad011. QJM. 2023. PMID: 36661317 Free PMC article. Review.
Of Flies and Men-The Discovery of TLRs.
Weiss HJ, O'Neill LAJ. Weiss HJ, et al. Cells. 2022 Oct 5;11(19):3127. doi: 10.3390/cells11193127. Cells. 2022. PMID: 36231089 Free PMC article. Review.
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