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Decitabine cytotoxicity is promoted by dCMP deaminase DCTD and mitigated by SUMO-dependent E3 ligase TOPORS.
Carnie CJ, Götz MJ, Palma-Chaundler CS, Weickert P, Wanders A, Serrano-Benitez A, Li HY, Gupta V, Awwad SW, Blum CJ, Sczaniecka-Clift M, Cordes J, Zagnoli-Vieira G, D'Alessandro G, Richards SL, Gueorguieva N, Lam S, Beli P, Stingele J, Jackson SP. Carnie CJ, et al. EMBO J. 2024 Jun;43(12):2397-2423. doi: 10.1038/s44318-024-00108-2. Epub 2024 May 17. EMBO J. 2024. PMID: 38760575 Free PMC article.