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Fibrosis: from mechanisms to medicines.
Henderson NC, Rieder F, Wynn TA. Henderson NC, et al. Nature. 2020 Nov;587(7835):555-566. doi: 10.1038/s41586-020-2938-9. Epub 2020 Nov 25. Nature. 2020. PMID: 33239795 Free PMC article. Review.
Decoding myofibroblast origins in human kidney fibrosis.
Kuppe C, Ibrahim MM, Kranz J, Zhang X, Ziegler S, Perales-Patón J, Jansen J, Reimer KC, Smith JR, Dobie R, Wilson-Kanamori JR, Halder M, Xu Y, Kabgani N, Kaesler N, Klaus M, Gernhold L, Puelles VG, Huber TB, Boor P, Menzel S, Hoogenboezem RM, Bindels EMJ, Steffens J, Floege J, Schneider RK, Saez-Rodriguez J, Henderson NC, Kramann R. Kuppe C, et al. Nature. 2021 Jan;589(7841):281-286. doi: 10.1038/s41586-020-2941-1. Epub 2020 Nov 11. Nature. 2021. PMID: 33176333 Free PMC article.
Liver zonation, revisited.
Paris J, Henderson NC. Paris J, et al. Hepatology. 2022 Oct;76(4):1219-1230. doi: 10.1002/hep.32408. Epub 2022 Mar 6. Hepatology. 2022. PMID: 35175659 Free PMC article. Review.
Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis.
Filliol A, Saito Y, Nair A, Dapito DH, Yu LX, Ravichandra A, Bhattacharjee S, Affo S, Fujiwara N, Su H, Sun Q, Savage TM, Wilson-Kanamori JR, Caviglia JM, Chin L, Chen D, Wang X, Caruso S, Kang JK, Amin AD, Wallace S, Dobie R, Yin D, Rodriguez-Fiallos OM, Yin C, Mehal A, Izar B, Friedman RA, Wells RG, Pajvani UB, Hoshida Y, Remotti HE, Arpaia N, Zucman-Rossi J, Karin M, Henderson NC, Tabas I, Schwabe RF. Filliol A, et al. Nature. 2022 Oct;610(7931):356-365. doi: 10.1038/s41586-022-05289-6. Epub 2022 Oct 5. Nature. 2022. PMID: 36198802 Free PMC article.
An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis.
Wang S, Li K, Pickholz E, Dobie R, Matchett KP, Henderson NC, Carrico C, Driver I, Borch Jensen M, Chen L, Petitjean M, Bhattacharya D, Fiel MI, Liu X, Kisseleva T, Alon U, Adler M, Medzhitov R, Friedman SL. Wang S, et al. Sci Transl Med. 2023 Jan 4;15(677):eadd3949. doi: 10.1126/scitranslmed.add3949. Epub 2023 Jan 4. Sci Transl Med. 2023. PMID: 36599008 Free PMC article.
Genome-Wide Association Study of NAFLD Using Electronic Health Records.
Fairfield CJ, Drake TM, Pius R, Bretherick AD, Campbell A, Clark DW, Fallowfield JA, Hayward C, Henderson NC, Joshi PK, Mills NL, Porteous DJ, Ramachandran P, Semple RK, Shaw CA, Sudlow CLM, Timmers PRHJ, Wilson JF, Wigmore SJ, Harrison EM, Spiliopoulou A. Fairfield CJ, et al. Hepatol Commun. 2022 Feb;6(2):297-308. doi: 10.1002/hep4.1805. Epub 2021 Sep 17. Hepatol Commun. 2022. PMID: 34535985 Free PMC article.
Human and murine fibroblast single-cell transcriptomics reveals fibroblast clusters are differentially affected by ageing and serum cholesterol.
van Kuijk K, McCracken IR, Tillie RJHA, Asselberghs SEJ, Kheder DA, Muitjens S, Jin H, Taylor RS, Wichers Schreur R, Kuppe C, Dobie R, Ramachandran P, Gijbels MJ, Temmerman L, Kirkwoord PM, Luyten J, Li Y, Noels H, Goossens P, Wilson-Kanamori JR, Schurgers LJ, Shen YH, Mees BME, Biessen EAL, Henderson NC, Kramann R, Baker AH, Sluimer JC. van Kuijk K, et al. Cardiovasc Res. 2023 Jul 4;119(7):1509-1523. doi: 10.1093/cvr/cvad016. Cardiovasc Res. 2023. PMID: 36718802 Free PMC article.
Macrophages promote anti-androgen resistance in prostate cancer bone disease.
Li XF, Selli C, Zhou HL, Cao J, Wu S, Ma RY, Lu Y, Zhang CB, Xun B, Lam AD, Pang XC, Fernando A, Zhang Z, Unciti-Broceta A, Carragher NO, Ramachandran P, Henderson NC, Sun LL, Hu HY, Li GB, Sawyers C, Qian BZ. Li XF, et al. J Exp Med. 2023 Apr 3;220(4):e20221007. doi: 10.1084/jem.20221007. Epub 2023 Feb 7. J Exp Med. 2023. PMID: 36749798 Free PMC article.
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