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Page 1
Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer.
Nalio Ramos R, Missolo-Koussou Y, Gerber-Ferder Y, Bromley CP, Bugatti M, Núñez NG, Tosello Boari J, Richer W, Menger L, Denizeau J, Sedlik C, Caudana P, Kotsias F, Niborski LL, Viel S, Bohec M, Lameiras S, Baulande S, Lesage L, Nicolas A, Meseure D, Vincent-Salomon A, Reyal F, Dutertre CA, Ginhoux F, Vimeux L, Donnadieu E, Buttard B, Galon J, Zelenay S, Vermi W, Guermonprez P, Piaggio E, Helft J. Nalio Ramos R, et al. Cell. 2022 Mar 31;185(7):1189-1207.e25. doi: 10.1016/j.cell.2022.02.021. Epub 2022 Mar 23. Cell. 2022. PMID: 35325594 Free article.
Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity.
Hutton C, Heider F, Blanco-Gomez A, Banyard A, Kononov A, Zhang X, Karim S, Paulus-Hock V, Watt D, Steele N, Kemp S, Hogg EKJ, Kelly J, Jackstadt RF, Lopes F, Menotti M, Chisholm L, Lamarca A, Valle J, Sansom OJ, Springer C, Malliri A, Marais R, Pasca di Magliano M, Zelenay S, Morton JP, Jørgensen C. Hutton C, et al. Cancer Cell. 2021 Sep 13;39(9):1227-1244.e20. doi: 10.1016/j.ccell.2021.06.017. Epub 2021 Jul 22. Cancer Cell. 2021. PMID: 34297917 Free PMC article.
Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity.
Giampazolias E, Schulz O, Lim KHJ, Rogers NC, Chakravarty P, Srinivasan N, Gordon O, Cardoso A, Buck MD, Poirier EZ, Canton J, Zelenay S, Sammicheli S, Moncaut N, Varsani-Brown S, Rosewell I, Reis e Sousa C. Giampazolias E, et al. Cell. 2021 Jul 22;184(15):4016-4031.e22. doi: 10.1016/j.cell.2021.05.021. Epub 2021 Jun 2. Cell. 2021. PMID: 34081922 Free PMC article.
Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.
Bonavita E, Bromley CP, Jonsson G, Pelly VS, Sahoo S, Walwyn-Brown K, Mensurado S, Moeini A, Flanagan E, Bell CR, Chiang SC, Chikkanna-Gowda CP, Rogers N, Silva-Santos B, Jaillon S, Mantovani A, Reis e Sousa C, Guerra N, Davis DM, Zelenay S. Bonavita E, et al. Immunity. 2020 Dec 15;53(6):1215-1229.e8. doi: 10.1016/j.immuni.2020.10.020. Epub 2020 Nov 20. Immunity. 2020. PMID: 33220234 Free PMC article.
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens.
Canton J, Blees H, Henry CM, Buck MD, Schulz O, Rogers NC, Childs E, Zelenay S, Rhys H, Domart MC, Collinson L, Alloatti A, Ellison CJ, Amigorena S, Papayannopoulos V, Thomas DC, Randow F, Reis e Sousa C. Canton J, et al. Nat Immunol. 2021 Feb;22(2):140-153. doi: 10.1038/s41590-020-00824-x. Epub 2020 Dec 21. Nat Immunol. 2021. PMID: 33349708 Free PMC article.
IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity.
Molgora M, Bonavita E, Ponzetta A, Riva F, Barbagallo M, Jaillon S, Popović B, Bernardini G, Magrini E, Gianni F, Zelenay S, Jonjić S, Santoni A, Garlanda C, Mantovani A. Molgora M, et al. Nature. 2017 Nov 2;551(7678):110-114. doi: 10.1038/nature24293. Epub 2017 Oct 25. Nature. 2017. PMID: 29072292 Free PMC article.
DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells.
Cueto FJ, Del Fresno C, Brandi P, Combes AJ, Hernández-García E, Sánchez-Paulete AR, Enamorado M, Bromley CP, Gomez MJ, Conde-Garrosa R, Mañes S, Zelenay S, Melero I, Iborra S, Krummel MF, Sancho D. Cueto FJ, et al. J Immunother Cancer. 2021 May;9(5):e002054. doi: 10.1136/jitc-2020-002054. J Immunother Cancer. 2021. PMID: 33980589 Free PMC article.
17 results