This study investigated the association between serum 25(OH)D3 levels and cardiovascular risk-related indicators. 4 727 participants aged 20 and above from the National Health and Nutrition Examination Survey 2015-2018 database were enrolled. Body mass index, hypersensitive C-reactive protein, high density lipoprotein cholesterol, systolic blood pressure, waist-height ratio, and total cholesterol were selected as the research indicators. Weighted multiple linear regression models, subgroup analyses, smooth curve fitting, and saturation threshold effect analyses were employed to explore the relationship between serum 25(OH)D3 and these indicators. The results showed that after full adjustment for covariates, every 1 nmol/L increase in serum 25(OH)D3, the changes in β (95%CI) values for body mass index(BMI), hypersensitive C-reactive protein(hs-CRP), systolic blood pressure(SBP), waist-height ratio(WHtR), high density lipoprotein cholesterol(HDL-C), and total cholesterol(TC) were -0.05 (-0.06, -0.04) kg/m2, -0.01 (-0.02, -0.01) mg/L, -0.02 (-0.04, -0.01) mmHg, -0.000 7 (-0.000 8, -0.000 6), 0.10 (0.08, 0.11) mg/dl, and 0.08 (0.04, 0.12) mg/dl, respectively. Female participants were more sensitive to changes in serum 25(OH)D3, while participants aged 60 and above were relatively less sensitive. The relationship between serum 25(OH)D3 and these indicators partially exhibited nonlinear patterns across different gender and age subgroups. The saturation threshold effect analysis revealed 8 meaningful inflection points. In summary, vitamin D has a close association with cardiovascular risk-related indicators.
本研究探讨血清 25（OH）D3与心血管风险相关指标的关联。纳入2015—2018年国家健康与营养调查20岁以上（含20岁）参与者4 727名。选取体重指数、高敏C反应蛋白、高密度脂蛋白胆固醇、收缩压、腰高比和总胆固醇作为研究指标。加权多元线性回归模型、亚组分析、平滑曲线拟合和饱和阈值效应分析用于研究血清 25（OH）D3与上述指标之间的关联。结果显示，在完全调整协变量后，血清25（OH）D3每增加1 nmol/L，体重指数（BMI）、高敏C反应蛋白（hs-CRP）、收缩压（SBP）、腰高比（WHtR）、高密度脂蛋白胆固醇（HDL-C）和总胆固醇（TC）的变化水平β（95%CI）值分别为-0.05（-0.06，-0.04）kg/m2、-0.01（-0.02，-0.01）mg/L、-0.02（-0.04，-0.01）mmHg、-0.000 7（-0.000 8，-0.000 6）、0.10（0.08，0.11）mg/dl、0.08（0.04，0.12）mg/dl。女性参与者对血清25（OH）D3的变化更为敏感，而60岁以上（含60岁）的人群则相对不敏感。血清25（OH）D3与上述指标在不同性别、年龄亚组中部分呈现非线性关系，饱和阈值效应分析提示了8个有意义的拐点。综上，维生素D与心血管风险相关指标间存在密切联系。.