25043/CAPMC/ CIHR/Canada[Grants and Funding] - Search Results

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2011	1
2012	2
2024	0

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Predicting P-glycoprotein-mediated drug transport based on support vector machine and three-dimensional crystal structure of P-glycoprotein.

Bikadi Z, Hazai I, Malik D, Jemnitz K, Veres Z, Hari P, Ni Z, Loo TW, Clarke DM, Hazai E, Mao Q. Bikadi Z, et al. PLoS One. 2011;6(10):e25815. doi: 10.1371/journal.pone.0025815. Epub 2011 Oct 4. PLoS One. 2011. PMID: 21991360 Free PMC article.

The ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely together.

Loo TW, Bartlett MC, Detty MR, Clarke DM. Loo TW, et al. J Biol Chem. 2012 Aug 3;287(32):26806-16. doi: 10.1074/jbc.M112.376202. Epub 2012 Jun 14. J Biol Chem. 2012. PMID: 22700974 Free PMC article.

Thiorhodamines containing amide and thioamide functionality as inhibitors of the ATP-binding cassette drug transporter P-glycoprotein (ABCB1).

Orchard A, Schamerhorn GA, Calitree BD, Sawada GA, Loo TW, Claire Bartlett M, Clarke DM, Detty MR. Orchard A, et al. Bioorg Med Chem. 2012 Jul 15;20(14):4290-302. doi: 10.1016/j.bmc.2012.05.075. Epub 2012 Jun 7. Bioorg Med Chem. 2012. PMID: 22727780 Free PMC article.

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