Chitosan and Chitooligosaccharides: Antifungal Potential and Structural Insights

Chem Biodivers. 2024 Jun;21(6):e202400044. doi: 10.1002/cbdv.202400044. Epub 2024 May 9.

Abstract

Chitosan is a cationic polysaccharide derived from chitin deacetylation. This polysaccharide and its oligosaccharides have many biological activities and can be used in several fields due to their favorable characteristics, such as biodegradability, biocompatibility, and nontoxicity. This review aims to explore the antifungal potential of chitosan and chitooligosaccharides along with the conditions used for the activity and mechanisms of action they use to kill fungal cells. The sources, chemical properties, and applications of chitosan and chitooligosaccharides are discussed in this review. It also addresses the threat fungi pose to human health and crop production and how these saccharides have proven to be effective against these microorganisms. The cellular processes triggered by chitosan and chitooligosaccharides in fungal cells, and prospects for their use as potential antifungal agents are also examined.

Keywords: antifungal potential; antifungal treatment; oligosaccharides.

Publication types

  • Review

MeSH terms

  • Antifungal Agents* / chemical synthesis
  • Antifungal Agents* / chemistry
  • Antifungal Agents* / pharmacology
  • Chitin / analogs & derivatives
  • Chitin / chemistry
  • Chitin / pharmacology
  • Chitosan* / chemistry
  • Chitosan* / pharmacology
  • Fungi* / drug effects
  • Humans
  • Microbial Sensitivity Tests
  • Oligosaccharides* / chemistry
  • Oligosaccharides* / pharmacology

Substances

  • Chitosan
  • Antifungal Agents
  • Oligosaccharides
  • Chitin
  • oligochitosan